Values of alpha defensin and C-reactive protein in synovial fluid in the diagnosis of periprosthetic infection

doi:10.12307/2021.194

Abstract

Abstract: BACKGROUND: Peri-prosthesis infections are one of the most common and serious complications of knee/hip replacement, accounting for 25% of total knee replacement failures and 16% of total hip replacement failures. Therefore, timely and accurate diagnosis of periarticular prosthesis infection has important clinical significance.
OBJECTIVE: To evaluate the diagnostic effects of α defensin and C-reactive protein on periprosthetic infections.
METHODS: Patients with pain following primary or revision joint surgery from September 2014 to September 2016 were selected for alpha defenesin and C-reactive protein testing in synovial fluid. The results were compared with Muscular Skeletal Infection Society standard, and the positive predictive value and negative predictive value were calculated. The trial was approved by the Ethics Committee of Guangzhou University of Chinese Medicine (approval No. K[2020]064) on August 7, 2020.
RESULTS AND CONCLUSION: The sensitivity and specificity of α defensin test combined with synovial fluid C-reactive protein positive test were 81.1% (95% CI: 64.8%-92.0%) and 95.9% (95% CI: 91.3%-98.5%). The sensitivity and specificity of α defensin and C-reactive protein in synovial fluid were 73.0% (95% CI: 55.9%-86.2%) and 99.3% (95% CI: 96.2%-99.9%). It is concluded that both α defensin and C-reactive protein in synovial fluid can be used in the diagnosis of periarticular infection.

Key words: alpha defensins, C-reactive protein, periprosthetic infection, clinical evaluation, joint replacement, postoperative pain, complications, diagnostic test

CLC Number:

He Shengcai, Jiang Chengdan, Jing Chunxiang, Luo Minyi, Ma Xingfa, Li Jiazhou, Pan Huashan. Values of alpha defensin and C-reactive protein in synovial fluid in the diagnosis of periprosthetic infection[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(27): 4344-4347.

Figures/Tables 2

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