Selection of injury segments in a rat model of spinal cord injury: network meta-analysis

doi:10.3969/j.issn.2095-4344.1047

Abstract

Abstract:

BACKGROUND: Allen’s weight-drop method has become a safe and effective modeling method, and choosing the injury segments of the spinal cord is an important factor for establishing ideal animal models of spinal cord injury.

OBJECTIVE: To compare the the similarities and differences in the effectiveness of spinal cord injury at T₈, T₉, T₁₀, T₁₁, and T₁₂ in Sprague-Dawley rats by network meta-analysis, thus providing evidence for the selection of lesion segments in rat models of spinal cord injury.

METHODS: PubMed, CNKI, VIP and WanFang databases were searched with the keywords of “spinal cord injuries, rats, models, animal, BBB scores” in English and Chinese, respectively for the literature published before June 5, 2018. The inclusion criteria were as follows: the modeling method of spinal cord injury was Allen's weight-drop (25 g·cm) method, rats only undergoing laminectomy were included in sham operation group, and low extremity function was assessed by Basso Beattie Bresnahan scores at 3, 7, 14 and 28 days. The order of the effectiveness of spinal cord injury at T₈, T₉, T₁₀, T₁₁, and T₁₂ was compared by network meta-analysis.

RESULTS AND CONCLUSION: (1) Nineteen studies were included, involving 703 rats. (2) Basso Beattie Bresnahan scores in the spinal cord injury rats at different segments at 3, 7, 14 and 28 days were significantly decreased compared with the sham operation group (P ≤ 0.05). (3) Spinal cord injury at T₁₀ showed largest effect on Beattie Bresnahan scores. (4) The order of effectiveness of spinal cord injury at different segments was: T₁₀ > T₉ > T₁₁ > T₈ > T₁₂> sham operation.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Spinal Cord Injuries, Models, Animal, Meta-Analysis

CLC Number:

R446
R318

Wei Weibing, Zou Zhilong, Zhou Binbin, Li Bolin, Qin Jingyu, Feng Zhenfen, Li Jiannan, Ye Liangying,Wu Rongmi. Selection of injury segments in a rat model of spinal cord injury: network meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(4): 650-656.

Figures/Tables 6

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