Seven joints ultrasonic score and superoxide dismutase measurement for assessing the activity of rheumatoid arthritis

doi:10.3969/j.issn.2095-4344.0861

Abstract

Abstract:

BACKGROUND: Rheumatoid arthritis (RA) is a chronic, autoimmune disease involving multiple joints throughout the body. Patients with RA exhibit abnormal oxidative stress, suggesting that oxidative stress is involved in the process of RA. Ultrasound is a commonly used imaging method for assessing the efficacy of RA.
OBJECTIVE: To explore the value of seven joints ultrasonic score and superoxide dismutase level in the evaluation of activity of RA.
METHODS: A total of 163 patients with RA who received treatment in the Department of Rheumatology and Immunology, Affiliated Hospital of Guilin Medical University from April 2016 to April 2017 were selected and divided into two groups based on disease activity score 28 (DAS28) remission (n=20), mild (n=30), moderate (n=70), and severe activity (n=43). Another 50 cases who received health examination at the same period were included. All subjects were tested for serum superoxide dismutase level. High-frequency ultrasound was used to observe the superior limbs of seven joints in patients with RA and to evaluate the US7 score. US7 score and superoxide dismutase level were used to assess the disease activity of RA.
RESULTS AND CONCLUSION: The level of serum superoxide dismutase in patients with mild, moderate and severe active RA was significantly higher than that in the healthy controls and remission of RA patients. In US7 score, patients with severe active RA had higher
synovitis gray scale ultrasound score, power Doppler ultrasound score, tenosynovitis and tendonitis gray scale ultrasound scores than patients in the remission period. There was no significant difference in bone erosion in all activities of rheumatoid arthritis between patients. The level of superoxide dismutase was negatively correlated with the gray scale ultrasound score of synovitis, the power Doppler score of synovitis, the DAS28 and the rheumatoid factor. DAS28 was positively correlated with synovitis gray scale, synovitis power Doppler score, tenosynovitis and tendonitis gray scale ultrasound scores and tenosynovitis and tendonitis power Doppler score. DAS28 and superoxide dismutase showed no significant correlation with bone erosion. These findings suggest that the index of superoxide dismutase and the score of US7 in addition to bone erosion are closely related to DAS28. Detection of superoxide dismutase level and US7 scores can be used to assess the disease activity of RA.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Arthritis, Rheumatoid, Ultrasonography, Tissue Engineering

CLC Number:

R318

Xu Jia1, Gao Song2, Mo Han-you1, Shi Yu-hong1. Seven joints ultrasonic score and superoxide dismutase measurement for assessing the activity of rheumatoid arthritis[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(24): 3773-3779.

Figures/Tables 3

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