Correlation of cytokine levels in the peripheral blood within 24 hours after cervical spinal cord injury with the American Spinal Injury Association impairment scale:   a comparative study

doi:10.3969/j.issn.2095-4344.0809

Abstract

Abstract:

BACKGROUND: Cytokines play a critical role in the pathophysiologic mechanism of spinal cord injury (SCI). Direct or indirect inhibition or alleviation of immune inflammatory reactions following SCI can improve the patient’s prognosis and recovery of neurologic function.
OBJECTIVE: To investigate the correlation between the levels of interleukin-1β, interleukin-6, interleukin-10, tumor necrosis factor-α, transforming growth factor-β1 and interferon-γ in the peripheral blood of patients with early cervical SCI and the American Spinal Injury Association (ASIA) impairment scale, and explore the role of cytokine-mediated immune inflammatory responses in the pathogenesis of cervical SCI.
METHODS: Thirty patients with cervical SCI and 20 healthy controls were enrolled. The levels of related cytokines in the peripheral blood were detected by ELISA. According to the ASIA impairment scale, all patients were divided into two groups: complete SCI group (Grade A, 10 cases) and incomplete SCI group (Grade B+C+D+E, 20 cases).
RESULTS AND CONCLUSION: The levels of interleukin-1β, interleukin-6 and transforming growth factor-β1 in the peripheral blood in the SCI patients were significantly higher than those in the control group. The level of transforming growth factor-β1 in the peripheral blood of the complete SCI patients was significantly higher than that of incomplete SCI patients. Our findings imply that the levels of interleukin-1β, interleukin-6 and transforming growth factor-β1 in the peripheral blood of patients with cervical SCI in early period are increased significantly, and the level of transforming growth factor-β1 is associated with the severity of SCI, suggesting that there is a correlation between dysfunction of nervous system and immune response post-cervical SCI.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Spinal Cord Injuries, Cytokines, Interleukin-1beta, Interleukin-6, Transforming Growth Factor beta1, Tissue

CLC Number:

R318

Zhang Yong, Shen Cai-liang, Dong Fu-long, Zhang Ren-jie, Ge Peng. Correlation of cytokine levels in the peripheral blood within 24 hours after cervical spinal cord injury with the American Spinal Injury Association impairment scale: a comparative study[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(24): 3824-3830.

Figures/Tables 2

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