Association of methylenetetrahydrofolate reductase C677T polymorphism with femoral head necrosis: a meta-analysis

doi:10.3969/j.issn.2095-4344.0580

Abstract

Abstract:

BACKGROUND: Whether methylenetetrahydrofolate reductase (MTHFR) gene C677T is the susceptible gene of femoral head necrosis diseases remains controversial.

OBJECTIVE: To evaluate the association of C677T polymorphism of MTHFR gene with the occurrence of femoral head necrosis.

METHODS: A computer-based retrieval of PubMed, Embase, the Cochrane Library, Web of Science, CBM, CNKI, VIP and WanFang databases was conducted for the case-control trials concerning MTHFR gene C677T polymorphism and femoral head necrosis published before January 2018. According to the inclusion and exclusion criteria, the literature was screened, the quality of the included literature was assessed and meta-analysis was performed. Heterogeneity test was conducted on Stata 12.0 software, and the index values of each odd ratio(OR) and 95% confidence interval (CI) were calculated. The publication bias was evaluated by funnel plot and Egger regression test.

RESULTS AND CONCLUSION: (1) Six articles involving 1 174 patients were enrolled, including 395 patients with femoral head necrosis and 779 healthy controls. (2) Meta-analysis results showed that the incidence of femoral head necrosis in MTHFR C677T carriers (CC or CT type) and wild-type patients (CC type) was related to the incidence of femoral head necrosis: CT+TT vs. CC genotype (OR=1.43, 95%CI (1.09-1.89), P=0.011); T vs. C (OR=1.46, 95%CI (1.19-1.78), P=0.000); TT vs. CT genotype (OR=1.91, 95%CI (1.28-2.86), P=0.002); TT vs. CC+CT genotype (OR=1.79, 95%CI (1.29-2.50), P=0.001). (3) Egger regression results showed no publication bias. (4) Meta-analysis results imply that the polymorphism of C677T in MTHFR gene was associated with the occurrence of femoral head necrosis.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Femur Head Necrosis, Methylenetetrahydrofolate Reductase, Genes, Evidence-Based Medicine, Tissue Engineering

CLC Number:

R446

Fan Siqi, Zeng Ping, Lai Chongrong, Liu Xiong. Association of methylenetetrahydrofolate reductase C677T polymorphism with femoral head necrosis: a meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2018, 22(35): 5730-5734.

Figures/Tables 3

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