Serum levels of inflammatory factors in patients with tibial bone defect treated by Ilizarov bone transport: X-ray assessment

doi:10.3969/j.issn.2095-4344.0379

Abstract

Abstract:

BACKGROUND: Therapeutic effects of traditional debridement and bone graft for tibial defect were obvious, but this method has a certain limitation in large bone defect.

OBJECTIVE: To observe the treatment therapy and serum levels of inflammatory factors in patients with tibia bone defect treated by Ilizarov bone transport.

METHODS: Seventy-eight patients with tibia bone defect were selected and randomized into observation group (n=40, Ilizarov bone transport) and control group (n=38, unilateral external fixator). The total effective rate of iconography was measured by radiography at postoperative 6 months. The clinical effect was measured by paley evaluation criterion. The incidence of complications was detected by 12-month follow-up. The serum levels of C-reactive protein, tumor necrosis factor-α and nuclear factor-κB were measured by ELISA.

RESULTS AND CONCLUSION: The difference was significant in the iconography effect between two groups at 6 months postoperatively (P < 0.05), total effective rate of iconography and excellent and good rate in the observation group were significantly higher than those in the control group (P < 0.05). At postoperative 12 months, the serum levels of C-reactive protein, tumor necrosis factor-α and nuclear factor-κB as well as incidence of complications in the observation group were significantly lower than those in the control group (P < 0.05). To conclude, Ilizarov bone transport is more effective compared with traditional remedies in tibia bone defect, and the incidence of complications is lower. It has a certain inhibitory effect on inflammatory factors.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Tissue Engineering, Tibia, Tumor Necrosis Factor-alpha

CLC Number:

R318

Zhang Song, Zhang Tao, Tong Chao, Lin Lian-yang, Zhang Yong-hong, Zhou Xue-ru . Serum levels of inflammatory factors in patients with tibial bone defect treated by Ilizarov bone transport: X-ray assessment[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(31): 5003-5008.

Figures/Tables 1

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