Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4242-4246.doi: 10.3969/j.issn.1673-8225.2012.23.013

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Transplantation of human bone morphogenetic protein-2 gene transfected autogenous bone marrow mesenchymal stem cells promotes bone regeneration in rabbit mandibular distraction osteogenesis: A histomorphological study

Huang Xuan-ping, Zhou Nuo, Jiang Xian-fang, Song Ji-zhuan, Li Hua, Xie Qing-tiao   

  1. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-08-23 Revised:2011-09-28 Online:2012-06-03 Published:2013-11-06
  • Contact: Zhou Nuo, Professor, Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China nuozhou@hotmail.com
  • About author:Huang Xuan-ping☆, M.D., Associate professor, Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China hxp120@126.com

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Abstract:

BACKGROUND: How to promote new bone formation and regeneration quality, shorten hospitalization and treatment times, and decrease related complications has recently been the edge-cutting focus in the field.
OBJECTIVE: To investigate the effect of human bone morphogenetic protein-2 gene transfected autogenous bone marrow mesenchymal stem cells transplantation on promoting rabbit bone regeneration in mandibular distraction osteogenesis by histomorphological method.
METHODS: Thirty-six New Zealand white rabbits were randomly divided into three groups with 12 rabbits in each. All the objects were prepared into distraction osteogenesis surgical models on the right mandible. On the 2nd day of consolidation period, rats in the experimental group, control group and blank group were injected with the same amount of human bone morphogenetic protein-2 gene transfected autogenous bone marrow mesenchymal stem cells, autogenous bone marrow mesenchymal stem cells and physiological saline at distraction gap, respectively.
RESULTS AND CONCLUSION: The quality of bone trabecula of the experimental group was better than that of the control group and blank group at 2 and 6 weeks of consolidation period. The transplantation of human bone morphogenetic protein-2 gene transfected autogenous bone marrow mesenchymal stem cells can effectively promote bone regeneration in rabbit mandibular distraction osteogenesis.

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