Abstract:

BACKGROUND: Serum inflammatory factors levels are elevated after stent implantation during early stage, such as post-surgery 24 hours. However, little is known about long-term changes in serum inflammatory factors levels.
OBJECTIVE: To evaluate histocompatibility of Partner and Cypher drug-eluting stents by observing change of serum inflammatory factor levels in patients with coronary heart disease, and to compare the effects of early rehabilitation training on quality of life of patients with coronary heart disease following implantation of two different drug-eluting stents.
METHODS: Totally 108 patients with acute myocardial infarction (AMI) admitted in the Third Hospital of Liaoning Medical University from 2007 to 2009 were chosen. All patients were assigned to Partner (implantion) group (n=58) and Cypher (implantion) group (n=50). Among them, 34 cases in Partner (implantion) group and 28 cases in Cypher (implantion) group received early rehabilitation training. Levels of interleukin-18 (IL-18), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) in serum were determined before stent implantation, 3 and 5 weeks after stent implantation. Quality of life of patients was evaluated at 5 weeks after stent implantation.
RESULTS AND CONCLUSION: Serum levels of IL-18, CRP and TNF-α between the patients not receiving rehabilitation training in Cypher and Partner groups were similar. Which indicated histocompatibility of Cypher and Partner stents are excellent, and no histocompatibility difference was observed between two kinds of stents. Serum levels of IL-18, CRP and TNF-α in patients receiving Cypher and Partner stents implantation were not affected by rehabilitation training, while quality of life in patients were improved following rehabilitation training.