Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (25): 4638-4642.doi: 10.3969/j.issn.1673-8225.2011.25.019

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Effect of platelet-rich gel on new bone formation and bone maintenance following tooth extraction

Wang Cheng-yong, Lu Meng, Lin Hai, Chen Wei-hu   

  1. Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou   350001, Fujian Province, China
  • Received:2011-03-25 Revised:2011-05-01 Online:2011-06-18 Published:2014-01-10
  • Contact: Chen Wei-hui, Doctor, Master’s supervisor, Associate professor, Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian Province, China
  • About author:Wang Cheng-yong★, Master, Physician, Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian Province, China yulong5270@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 31070838; the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry*

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Abstract:

BACKGROUND: Whether platelet-rich plasma can promote bone tissue regeneration or not is controversial.
OBJECTIVE: To explore the effect of platelet-rich plasma (PRP)/platelet-rich gel (PRG) on bone healing after tooth extraction by an animal model of denervation.
METHODS: The premolars of both sides were extracted from Beagle dogs, then a filling socket with PRP or PRG was introduced. The Beagle dogs were sacrificed at 2, 4, 8, 12 weeks. X-ray, CT scan, hematoxylin-eosin staining were used to detect the effect of PRP or PRG on the new bone formation and maintenance after tooth extraction.
RESULTS AND CONCLUSIOU: CT scan convinced that compared with group PRP and control, group PRG had more new bone at 2, 4, 8 weeks. While, histological analysis showed that only at 2,4 weeks, group PRG had the advantage of osteogenesis. At all time points, group PRG showed the lest difference of buccal –lingual height. At 12 weeks, the difference of buccal and lingual height in group PRG was still 2mm.PRG had the ability to promote early phase healing of extraction sockets. PRG showed the limited efficiency in bone maintenance when used exclusively after extraction.

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