Abstract:

BACKGROUND: Polyacrylamide hydrogel is a kind of soft tissue fillers, mainly used for augmentation via injection.
OBJECTIVE: To study the tissue pathology of breast lesions associated with polyacrylamide hydrogel injection for augmentation mammoplasty.
METHODS: Thirty-five cases of breast lesions after polyacrylamide hydrogel injection were studied by using hematoxylin-eosin staining, immunohistochemical staining, PAS and AB staining.
RESULTS AND CONCLUSION: Twenty-six cases showed foreign-body granuloma and 3 cases showed breast cancer in 35 cases of polyacrylamide hydrogel injection for augmentation mammoplasty. Incidence of foreign-body granuloma was 74.3%, and incidence of breast cancer was 8.6% after polyacrylamide hydrogel injection for augmentation mammoplasty. The process was composed of mutliple cysts, in which there were a lot of irregular blue foreign material, surrounded by foreign body giant cells and histiocyte. Some patients showed acute inflammation with abscess formation. There was coagulation necrosis in breast tissue, fat and muscle. There were intraductual proliferative lesions in the surrounding breast tissue. Polyacrylamide hydrogel has certain toxicity to human body and induces coagulation necrosis and foreign-body granuloma in tissue. It may be related to the development of breast cancer.