Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (25): 4575-4578.doi: 10.3969/j.issn.1673-8225.2011.25.005

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Optimization of the matrix formulation of enclosed dressing intelligent scaffolds by uniform design

Tang Na1, 2, Deng Ling1, Zhou Li-ping1, Guo Li3, Li Chao2, Cai Wen-zhi1   

  1. 1Southern Hospital, Southern Medical University, Guangzhou  510515, Guangdong Province, China
    2Futian People's Hospital, Guangdong Medical College, Shenzhen  518033, Guangdong Province, China
    3School of Nursing, Southern Medical University, Guangzhou  510515, Guangdong Province, China
  • Received:2010-10-02 Revised:2011-01-10 Online:2011-06-18 Published:2014-01-10
  • Contact: Cai Wen-zhi, Chief superintendent nurse, Doctoral supervisor, Southern Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China caiwzh@fimmu.com
  • About author:Tang Na★, Studying for master’s degree, Nurse-in-charge, Southern Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China; Futian People's Hospital, Guangdong Medical College, Shenzhen 518033, Guangdong Province, China prettymedictn@yahoo.com.cn
  • Supported by:

    Natural Science Foundation of Guangdong Province, China, No. 2004B30101019*

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Abstract:

BACKGROUND: In recent years, the wound dressing research has developed quickly, but few reports addressing the closed dressings prepared by traditional Chinese medicine combined with polymer composite, the efficacy of existing wound dressings is limited and not suitable for all wounds. But how to make polymer materials and traditional Chinese medicine to mix perfectly is a hot topic recently.
OBJECTIVE: To optimize the matrix formulation of enclosed dressing intelligent scaffolds.
METHODS: Multiple regression analysis with uniform design and SPSS 16.0 software was used to optimize the matrix formulation of enclosed dressing intelligent scaffolds and survey the aspects comprehensively, such as water absorption of dressing scaffolds, moisture content, relative moisture retention, hand evaluation indicators and so on.
RESULTS AND CONCLUSION: The optimum dressing scaffolds matrix formulation ratio was as follows: chitosan: gelatin: glycerol: polyvinyl alcohol: polyethylene glycol = 8.3∶4.4∶3.1∶3.7∶1, according to analysis of experimental data. It is indicated that the prescription ratio of the matrix formulation of enclosed dressing intelligent scaffolds is feasible. In addition, the technique of the enclosed dressing intelligent scaffolds is steerable.

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