Abstract:

BACKGROUND: Clinical studies have shown that the long-term efficacy of polymethylmethacrylate (PMMA) as a perfusion agent for percutaneous vertebroplasty (PVP) remains to be seen, because of the poor biological activity.
OBJECTIVE: To explore the experimental operation of a PVP filler material to meet the physical and chemical requirements with a new type of biological activity of the porous composite material, in order for the complex to lay the foundation of animal studies.
METHODS: Sodium bicarbonate, Osteoset-demineralized bone matrix (DBM) particles powder and PMMA bone cement were mixed at different mass ratio (1:40:60, 0:40:60, 1:0:100) to form A, B, C three kinds of composite materials. The solidification time, polymerization temperature, anti-scattered resistance, and resistance to stress were measured, and the ultrastructure was observed under scanning electron microscope (SEM).
RESULTS AND CONCLUSION: In A and B groups, the solidification time, polymerization temperature, and compressive strength significantly differed from those in C group, but all the materials met with PVP filler basic requirements with good anti-scattered nature. SEM showed the material in A group was looser with more pores than those in B and C groups. The composite material A has good physical and chemical properties, as the PVP technique can meet the basic conditions of filling materials, and has good pore structure. Further studies can be conducted on the biocompatibility, biodegradability, bone conduction, induction and other biological properties.