Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (23): 4347-4350.doi: 10.3969/j.issn.1673-8225.2010.23.037

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Adult neural cell regeneration after traumatic brain injury

Zhao Wang-miao, Huan Lin-chun, Yang Xin-yu   

  1. Department of Neurosurgery, General Hospital, Tianjin Medical University, Key Laboratory of Nerve Injury Variation and Regeneration, Tianjin Neurology Institute, Tianjin  300052, China
  • Online:2010-06-04 Published:2010-06-04
  • Contact: Yang Xin-yu, Doctor, Professor, Master’s supervisor, Department of Neurosurgery, General Hospital, Tianjin Medical University, Key Laboratory of Nerve Injury Variation and Regeneration, Tianjin Neurology Institute, Tianjin 300052, China paperxyyang@gmail.com
  • About author:Zhao Wang-miao, Studying for master’s degree, Department of Neurosurgery, General Hospital, Tianjin Medical University, Key Laboratory of Nerve Injury Variation and Regeneration, Tianjin Neurology Institute, Tianjin 300052, China miaomiao_218@ 163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30973090;

    the Natural Science Foundation of Tianjin City, No. 09JCZDJC17200*

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Abstract:

BACKGROUND: Traumatic brain injury can lead to serious neurological dysfunction. Basal research reveals that persistent endogenous neurogenesis exists in adult mammal brain, which may benefit for recovery of brain trauma.
OBJECTIVE: This article reviews some progresses of neurogenesis in the adult hippocampus, subventricular zone and cerebral cortex after traumatic brain injury to find effective measures to improve neurogenesis and restoration of neurological function.
METHODS: We searched the related articles with respect to adult neurogenesis after traumatic brain injury in Pubmed database, published from January 1998 to March 2010. The key words were “traumatic brain injury, neurogenesis, hippocampus, subventricular zone, cerebral cortex” in title/abstract field. The content of articles was related to trauma and adult neurogenesis, and the study area involves neurogenic region (hippocampus and subventricular zone) and nonneurogenic region cerebral cortex. The articles which are newly issued or published in authoritative magazines were selected. In total 213 articles were included in initial search and 33 articles were selected to review according to inclusion criteria.
RESULTS AND CONCLUSION: Neurogenesis existed in the adult nervous system. Moderate brain trauma could stimulate neurogenesis of hippocampus and subventricular zone, and neurogenesis contributed to restoration of hippocampal function. Some exogenous factors which can promote neurogenesis can also improve neurological function. Resting neural progenitor cells exist in the cerebral cortex. The latent cells will re-entry the cell cycle and induce neurogenesis under certain conditions and they may benefit for the recovery of brain trauma.

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