Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (23): 4351-4354.doi: 10.3969/j.issn.1673-8225.2010.23.038

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Role of Notch signal transduction pathway in never repair and regeneration

Wang Kai1, Zhao Bin1, Wang Shuan-ke1, Wang Na2   

  1. 1Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou  730000, Gansu Province, China;
    2Department of Oncology, First Hospital of Lanzhou University, Lanzhou  730000, Gansu Province, China
  • Online:2010-06-04 Published:2010-06-04
  • Contact: Zhao Bin, Associate chief physician, Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China zhaobin05@126.com
  • About author:Wang Kai, Studying for master’s degree, Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China 56966186@qq.com
  • Supported by:

    the Natural Science Foundation of Gansu Province, No. 096RJZA078*

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Abstract:

BACKGROUND: Neural stem cells differentiate into functional neurocytes though equity cleavage, thereby recovery function of damaged cells. Notch signal transduction determines neurons differentiating into neurons and gliocytes.
OBJECTIVE: To summarize Notch structure, adjusting mechanism, influence factors, and effect on neurocytes.
METHODS: Articles addressing signal transduction, differentiation and development of neural stem cells, and spinal cord injury were retrieved from CNKI and PubMed database with the key words of “Notch, neurocyte, neural repair, neural regeneration” or “signal transduction, NSC, SCI, Notch”. A total of 430 articles were retrieved, and 31 ones were included in the final analysis.
RESULTS AND CONCLUSION: Effect of Notch on nerve repair and regeneration were mainly discussed. The Notch could selectively activate multi-functional neural stem cells in vitro and embryonic prosencephalic radiated neuroglia in vivo; moreover, activation is necessary for star-like neuroglia during the development, because it played an important role in adjusting development, growth, and apoptosis of other functional cells.

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