Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (23): 4342-4346.doi: 10.3969/j.issn.1673-8225.2010.23.036

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Research and application of stem cell transplantation for treatment of heart disease

Li Mu, Song Jian-fei, Liang Yue-pei, Li An-gui, Wang Wei   

  1. Department of Cardiothoracic Surgery, Affiliated Hospital of Guilin Medical College, 541001, Guangxi Zhuang Autonomous Region, China
  • Online:2010-06-04 Published:2010-06-04
  • About author:Li Mu, Master, Attending physician, Department of Cardiothoracic Surgery, Affiliated Hospital of Guilin Medical College, 541001, Guangxi Zhuang Autonomous Region, China tiantan_911@163. com

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Abstract:

BACKGROUND: With the development of end-stage heart disease, heart disease can not be cured fundamentally due to lots of limitations and existing treatments. Stem cells are mature cells of various origin cells, with self-renewal and differentiation potential. Stem cells have a strong regenerative capacity to replace, repair or strengthen damaged tissues or organs of biological functions. In theory, it is possible to cure cardiovascular disease eventually. However, numerous studies have suggested that stem cell transplantation treatment is safe and effective.
OBJECTIVE: To summarize the clinical research progress in stem cell transplantation in treatment of heart disease.
METHODS: The first author retrieved PubMed Database (http://www.ncbi.nlm.nih.gov/PubMed) for related articles published from January 1999 to October 2006, with the key words of “stem cells, transplant, heart disease” in English. Simultaneously, a computer-based search was performed in China Journal Full-text Database (http://www.wanfangdata.com.cn) for relevant articles published from January 1999 to October 2006 with the key words of “stem cells, transplant, heart disease” in Chinese. A total of 60 literatures were retrieved.
RESULTS AND CONCLUSION: Various types of heart disease developed to the final stage, the healthy myocardial cells cannot satisfy the needs of the body due to irreversible damage to the structure and function of myocardial cells. Moreover, varied palliative conservative treatments can not achieve satisfactory degree due to inability to solve the fundamental problem. However, the heart transplantation has been greatly limited, due to difficulties in obtaining donor, immunological rejection, high cost and high risk. These provide challenges for clinical treatment. Looking for a more effective treatment and opening up new treatment approaches have become inevitable. With the development of tissue and cell engineering research, the function recovery and reconstruction of stem cell transplantation therapies have become the hot research prospect.

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