Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (15): 2410-2415.doi: 10.12307/2024.411

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Advantages and features of nanocomposite hydrogel in treatment of osteoarthritis

Tian Linling1, Guo Hairui1, Du Xiaoming1, Feng Jie1, Zhang Xianzhe1, Zhang Wenbin1, Sun Haoran1, Zhang Xiaobin2, Wang Jingxia2, Hu Yimei1, 3, Wang Yi4   

  1. 1Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China; 2Sichuan Atomic Energy Research Institute, Chengdu 610199, Sichuan Province, China; 3Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China; 4Southwest Jiaotong University, Chengdu 610031, Sichuan Province, China
  • Received:2023-05-30 Accepted:2023-07-17 Online:2024-05-28 Published:2023-09-23
  • Contact: Hu Yimei, PhD, Professor, Master’s supervisor, Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China; Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China Wang Yi, PhD, Professor, Master’s supervisor, Southwest Jiaotong University, Chengdu 610031, Sichuan Province, China
  • About author:Tian Linling, Master candidate, Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 325021015 (to HYM); Science and Technology Department of Chengdu University of Traditional Chinese Medicine, Nos. 030058047, 030038164 (to HYM); “Hundred Talents Plan” for Improving the Scientific Research Ability of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, No. 22-B07 (to HYM); International Cooperation Project of Sichuan Provincial Department of Science and Technology, No. 2020YFH0052 (to WY); Central University Basic Research Business Fee Project, No. 2682022ZTPY038 (to WY)

Abstract: BACKGROUND: Nanocomposite hydrogel has great research prospects and application potential in the treatment of osteoarthritis.
OBJECTIVE: To review the research progress of nanocomposite hydrogel in osteoarthritis and cartilage repair.
METHODS: Databases such as CNKI and PubMed were searched. The English key words were “nanocomposite hydrogel, nanogel, osteoarthritis, cartage, physical encapsulation, electrostatic interaction, covalent crosslinking”, and the Chinese key words were “nanocomposite hydrogel, nanogel, osteoarthritis, cartage, physical encapsulation, physical encapsulation, electrostatic effect, covalent cross-linking”. After an initial screening of all articles based on inclusion and exclusion criteria, 71 articles with high correlation were retained for review.
RESULTS AND CONCLUSION: In cell or animal experiments, nanocomposite hydrogel has the effect of improving osteoarthritis. Nanocomposite hydrogel can promote cartilage repair, improve the internal environment of osteoarthritis, and achieve the therapeutic purpose of osteoarthritis by improving the mechanical environment between joints, carrying targeted drugs, and promoting the chondrogenesis of seed cells. At present, the research of nanocomposite hydrogel in osteoarthritis disease still has a huge space to play. It is expected to open up a new way for the clinical treatment of osteoarthritis by continuing to deepen the research of material preparation and actively carrying out cell and animal experiments.

Key words: osteoarthritis, cartilage repair, cartilage tissue engineering, nanocomposite hydrogel, biomaterial, biological scaffold, cartilage scaffold, review

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