Neuroprotective effect of stem cell transplantation on cerebral ischemia-reperfusion injury in rats: a systematic review

doi:10.12307/2023.306

Abstract

Abstract: OBJECTIVE: To evaluate the effect of stem cell transplantation on the recovery of neurological function in rats with cerebral ischemia-reperfusion injury, in order to provide reference data for clinical application.
METHODS: CNKI, Wanfang, VIP, CBM, PubMed, The Cochrane Library, Web of Science and Embase databases were retrieved before October 19, 2021. A series of randomized controlled trials on stem cell transplantation for cerebral ischemia-reperfusion injury rats were included. Two researchers independently screened the literature and extracted the data. The bias risk was evaluated by SYRCLE animal experiment bias risk assessment tool and the data were analyzed by Stata 16.0 statistical software.
RESULTS: A total of 30 articles meeting inclusion criteria were included. Random effect model analysis results showed that compared with the control group, stem cell transplantation could effectively improve the neurological deficit score [SMD=-1.70, 95%CI(-2.18,-1.21)], reduce the cerebral infarction volume score [SMD=-6.49, 95%CI(-8.87, -4.19)], and inhibit the expression level of tumor necrosis factor α [SMD=-3.23, 95%CI(-4.49, -1.96)].
CONCLUSION: The evidence from the existing animal experiments shows that stem cell transplantation can effectively promote the recovery of nerve function and has a protective effect on the brain of cerebral ischemia-reperfusion injury rats. The results of indirect subgroup comparison showed that the efficacy of bone marrow mesenchymal stem cells was better than other types, and the efficacy of arterial transplantation was better than other approaches. However, the results of this systematic review are limited by the quality and quantity of included studies, and its conclusions and clinical application effects need to be further confirmed by more and higher-quality studies.

Key words: stem cell, transplantation, cerebral ischemia-reperfusion injury, systematic review, meta-analysis, rat

CLC Number:

Li Ruixin, Su Gang, Liu Jifei, Xu Dan, Gao Xin, Ma Tianfei, Zhang Zhenchang. Neuroprotective effect of stem cell transplantation on cerebral ischemia-reperfusion injury in rats: a systematic review[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(10): 1634-1640.

Figures/Tables 7

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