Chinese Journal of Tissue Engineering Research ›› 2023, Vol. 27 ›› Issue (3): 335-338.doi: 10.12307/2023.021

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In vitro construction of Stanford type A aortic dissection 3D dynamic simulation diagram and individual tissue-engineered blood vessels

Cheng Mingguang1, Zhang Chaoyu2, Zhuang Kangle3, Ruan Peng1, Zuo Yi1, Zhou Zhengchun1, Kong Xiang1, Ge Jianjun1, Cheng Guangcun1   

  1. 1Department of Cardiac Surgery, First Affiliated Hospital (Anhui Provincial Hospital) of University of Science and Technology of China, Hefei 230001, Anhui Province, China; 2Anhui Medical University, Hefei 230032, Anhui Province, China; 3Anhui Zhongjian 3D Technology Co., Ltd., Wuhu 241000, Anhui Province, China
  • Received:2021-10-12 Accepted:2022-01-13 Online:2023-01-28 Published:2022-05-20
  • Contact: Cheng Guangcun, Professor, Chief physician, Department of Cardiac Surgery, First Affiliated Hospital (Anhui Provincial Hospital) of University of Science and Technology of China, Hefei 230001, Anhui Province, China
  • About author:Cheng Mingguang, Physician, Department of Cardiac Surgery, First Affiliated Hospital (Anhui Provincial Hospital) of University of Science and Technology of China, Hefei 230001, Anhui Province, China
  • Supported by:
    Key Research and Development Program of Anhui Province, No. 202004j07020018 (to CGC)

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Abstract: BACKGROUND: Stanford type A aortic dissection operation is difficult and complex, requiring total ascending aortic arch replacement and descending aortic stent implantation under deep hypothermic circulation arrest. The operator has high operational requirements. 
OBJECTIVE: To explore the feasibility of constructing Stanford type A aortic dissection 3D dynamic simulation diagram in vitro and preparing individual tissue-engineered blood vessels, so as to provide simulated surgical process for clinicians in the future.
METHODS: A total of 17 Stanford type A aortic dissection patients admitted to the First Affiliated Hospital (Anhui Provincial Hospital) of University of Science and Technology of China from January 2020 to July 2021 were selected and their image data were imported into medical image processing software. The simulation of Stanford type A aortic dissection was reconstructed. For the reconstructed aortic vessel model, the 3D dynamic simulation diagram of the dissection was developed, and the individual tissue-engineered vessels were developed. Meanwhile, the average difference between the aortic dissection model and aortic dissection CT angiography at different positions was measured.
RESULTS AND CONCLUSION: (1) Accurate formulation of 3D dynamic simulation diagram and model of interlayer could prepare individual tissue-engineered blood vessels to meet the needs of clinical artificial blood vessel materials. (2) In horizontal aorta at sinus canal junction, horizontal aorta of brachiocephalic trunk, horizontal aorta of left subclavian artery, brachiocephalic trunk, left common carotid artery and left subclavian artery, there was no significant difference between the inner diameter value of the 3D dynamic model of Stanford type A aortic dissection and the results of CT angiography (P > 0.05). (3) It is concluded that constructing 3D dynamic simulation diagram of Stanford type A aortic dissection in vitro and accurately printing the complex anatomical structure of Stanford type A aortic dissection can accurately prepare individual tissue-engineered blood vessels. 

Key words: aortic dissection, 3D dynamic simulation diagram, interlayer model, polylactic acid, tissue-engineered blood vessels, CT angiography

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