Abstract: OBJECTIVE: In recent years, a variety of new medical dressings have been used in the treatment of diabetic foot ulcer, and it is not clear which dressing has the best effect. Therefore, this study used network meta-analysis technology to systematically evaluate the efficacy of different new medical dressings in the treatment of diabetic foot ulcer.
METHODS: A computer search was conducted on CNKI, Wanfang Data Knowledge Service Platform, VIP, China Biomedical Literature Database, PubMed, EMbase, Cochrane Library, and Web of Science databases from the database establishment to November 2020. Randomized controlled trials of new medical dressings in the treatment of diabetic foot ulcer were included. The bias risk assessment tool of the Cochrane systematic evaluation was used to evaluate the quality of the included literature. Two researchers screened the literature and extracted relevant data. RevMan 5.3, ADDIS 1.16.6 and Stata 14.0 software were used for literature quality evaluation and data analysis.
RESULTS: A total of 33 randomized controlled trials involving 2 520 patients with diabetic foot ulcers were included, 10 of which were low-risk bias, 19 of which were medium-risk bias, and 4 of which were high-risk bias. Network meta-analysis results showed that (1) regarding the cure rate, the silver ion dressings, epidermal growth factor, platelet rich plasma, and amniotic membrane were superior to traditional dressings and alginate dressings; platelet rich plasma was better than that of the silver ion dressings; honey dressing was better than traditional dressings (P < 0.05). A probability results show that the top three dressings was platelet rich plasma, amniotic membrane, and epidermal growth factor. (2) In terms of healing time, silver ion dressings, epidermal growth factor and platelet rich plasma were all better than traditional dressings and alginate dressings, and honey dressings were all better than alginate dressings (P < 0.05). The probability results showed that epidermal growth factor, platelet rich plasma and silver ion dressings ranked the third. 
CONCLUSION: (1) Based on the results of 33 randomized controlled trials confirm that in many new medical dressings, platelet-rich plasma, epidermal growth factor, amniotic membrane, and silver ion dressings are superior to other dressings in the treatment of diabetic foot ulcer. In the cure rate of diabetic foot, the best dressing was platelet-rich plasma. In terms of healing time of diabetic foot ulcers, epidermal growth factor ranked best. 

Key words: biomaterial, diabetic foot, ulcer, new medical dressings, platelet-rich plasma, epidermal growth factor, randomized controlled trials, network meta-analysis