Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (31): 5046-5052.doi: 10.12307/2021.149

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Effect of urinary-derived stem cells and extracellular vesicles in tissue damage repair

Cui Tianning1, Liu Tao1, Xiao Xiangyang1, Wang Shuai2, Zhang Nini2, Huang Guilin2   

  1. 1Zunyi Medical University, Zunyi 563000, Guizhou Province, China; 2Department of Dentofacial Surgery, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • Received:2020-11-24 Revised:2020-11-30 Accepted:2021-01-09 Online:2021-11-08 Published:2021-04-25
  • Contact: Huang Guilin, MD, Professor, Master’s supervisor, Department of Dentofacial Surgery, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • About author:Cui Tianning, Master candidate, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81760201, 81960204 (to HGL); the National Natural Science Foundation of China, No. 81860198 (to ZNN)

Abstract: BACKGROUND: Mesenchymal stem cells and their extracellular vesicles have made great progress in promoting the repair and regeneration of tissue injury, which provides a promising clinical application for future cell-free therapeutic strategies.
OBJECTIVE: To review the repair of urinary-derived stem cells and their extracellular vesicles in the urinary system, the skeletal system, the nervous system, as well as the problems and prospects.
METHODS: PubMed and Wanfang databases were searched using “urine-derived stem cells, extracellular vesicles, tissue damage repair (bladder; bone; nerve tissue)” as Chinese and English search terms. The retrieve time range was from 1989 to 2020. By reading titles and abstracts for initial screening, repetitive studies and articles with irrelevant contents in English and Chinese literature were excluded. Finally, 62 articles were reviewed. 
RESULTS AND CONCLUSION: Urine-derived stem cells are a group of cells with multi-directional differentiation potential extracted from urine, and their biological characteristics were similar to mesenchymal stem cells and embryonic stem cells. Extracellular vesicles derived from urine-derived stem cells are a kind of new cell free treatment strategy, which is currently widely used in tissue repair in the urinary system, skeletal system and nervous system. At present, it is still in the small animal experimental study; however, a large number of trials are required to confirm the safety and feasibility of tissue engineering. Thus, the urine-derived stem cells and extracellular vesicles will become a hot spot in the field of regenerative medicine.

Key words: stem cells, urine-derived stem cells, extracellular vesicles, tissue damage, repair, urinary tissue, kidney, bone, nerve tissue, review

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