中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (43): 8009-8012.doi: 10.3969/j.issn.2095-4344.2012.43.007

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

不同pH值纳米羟基磷灰石复合根充糊剂的体外抑菌性

王健平1，王云锋1，冯 瑶1，岳长军2，董 波1   

  1. 1佳木斯大学口腔医学院，黑龙江省佳木斯市 154004
    2绥棱县医院，黑龙江省绥化市 152000
  • 收稿日期:2012-02-11 修回日期:2012-03-13 出版日期:2012-10-21 发布日期:2013-04-08
  • 通讯作者: 董波，主任医师，佳木斯大学口腔医学院，黑龙江省佳木斯市 154004 jmskqdb@ 163.com
  • 作者简介:王健平★，男，1959年生，黑龙江省佳木斯市人，汉族，1989年湖北医科大学毕业，硕士，主任医师，主要从事牙体牙髓病研究。 WJP.1959@ 163.com

Antimicrobial activity of nano-hydroxyapatite composite root canal filling materials with different pH values in vitro

Wang Jian-ping1, Wang Yun-feng1, Feng Yao1, Yue Chang-jun2, Dong Bo1   

  1. 1School of Stomatology, Jiamusi University, Jiamusi 154004, Heilongjiang Province, China
    2Suiling Hospital, Suihua 152000, Heilongjiang Province, China
  • Received:2012-02-11 Revised:2012-03-13 Online:2012-10-21 Published:2013-04-08
  • Contact: Dong Bo, Chief physician, School of Stomatology, Jiamusi University, Jiamusi 154004, Heilongjiang Province, China jmskqdb@163.com
  • About author:Wang Jian-ping★, Master, Chief physician, School of Stomatology, Jiamusi University, Jiamusi 154004, Heilongjiang Province, China WJP.1959@163.com

PDF

468

被引次数

2

摘要：

背景：目前临床应用的根管充填糊剂抗菌作用有限，存在组织刺激性强、成形困难、根管封闭性较差及易降解等缺点。
目的：比较不同pH值纳米羟基磷灰石复合根充糊剂对感染根管常见菌的体外抑菌作用。
方法：建立体外根管粪肠球菌、白色念球菌感染模型，评价pH 8纳米羟基磷灰石糊剂、pH 9纳米羟基磷灰石糊剂、pH 10纳米羟基磷灰石糊剂在离体牙根管内的抗菌作用，并以氧化锌丁香油做对照。
结果与结论：所有根充糊剂均具有抑菌作用。各pH值纳米羟基磷灰石糊剂对粪肠球菌抑制作用实验组优于氧化锌丁香油组(P < 0.05)，不同pH值纳米羟基磷灰石组组间比较差异无显著性意义(P > 0.05)。而对白色念珠菌抑制作用各pH值纳米羟基磷灰石组不及氧化锌丁香油组(P < 0.05)，各pH值纳米羟基磷灰石组组间比较，pH10纳米羟基磷灰石组>pH 9纳米羟基磷灰石组>pH 8纳米羟基磷灰石组(P < 0.05)。结果表明，感染根管模型中，纳米羟基磷灰石根充糊剂对粪肠球菌的抑制作用好于氧化锌丁香油(P < 0.05)，而对白色念珠菌的抑制作用不及氧化锌丁香油(P < 0.05)。pH=10纳米羟基磷灰石复合根充糊剂的抑菌作用最佳。

关键词: 纳米羟基磷灰石, 根充糊剂, 抑菌性, 生物膜, 根管

Abstract:

BACKGROUND: The antimicrobial activity of root canal filling materials in clinical application is limited at present. Root canal filling materials have detects, such as strong stimulation to tissues, difficulty in formation, bad root canal sealing and easy to be degradable.
OBJECTIVE: To study the effect of antimicrobial activity of nano-hydroxyapatite composite root canal filling materials with different pH values on common bacteria infected root canal in vitro.
METHODS: In vitro infected root canal model of enterococcus faecalis and candida albicans was established. The antibacterial property of nano-hydroxyapatite paste with different pH values in root canal in vitro was evaluated, including pH 8, pH 9 and pH 10. Zinc oxide eugenol were as a control.
RESULTS AND CONCLUSION: All the root canal filling materials have bacteriostatic effect. Compared with the control group, the inhibiting effect of nano-hydroxyapatite paste in each pH value group on enterococcus faecalis was better than that in the control group (P < 0.05). There was no significant difference among nano-hydroxyapatite paste in each pH value group (P > 0.05). The inhibitory effect of nano-hydroxyapatite paste in each pH value group on candida albicans was not better than that in the control group (P < 0.05). Nano-hydroxya paste in each pH value group was compared, and pH 10 group > pH 9 group > pH 8 group (P < 0.05). These findings suggest that in the model of infected root canal, the inhibiting effect of nano hydroxyapatite paste on enterococcus faecalis was better than that of zinc oxide eugenol (P < 0.05), but the inhibiting effect of nano-hydroxyapatite paste on candida albicans was not better than that of zinc oxide eugenol (P < 0.05). Besides, nano-hydroxyapatite composite root canal filling materials with pH=10 have the best bacteriostatic property.

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