中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (7): 1282-1285.doi: 10.3969/j.issn.1673-8225.2010.07.033

• 组织构建综述 tissue construction review • 上一篇    下一篇

关节软骨的损伤与修复：自体移植、基质诱导、内置支架及组织工程化培养

杨肖杰○1，夏长所2   

  1. 1澳大利亚墨尔本大学工程学院生物医学工程系，墨尔本 3010； 2青岛大学医学院附属医院关节外科，山东省青岛市 266003
  • 出版日期:2010-02-12 发布日期:2010-02-12
  • 作者简介:杨肖杰★，男，1984年生，山东省昌乐县人，汉族，澳大利亚墨尔本大学生物医学工程系在读硕士，主要从事细胞及组织工程方面的研究。jesse.modest@hotmail.com

Treatments of articular cartilage defects: Autologous chondrocyte implantation, matrix-induced autologous chondrocyte implantation, in vivo scaffolds and related tissue engineering technologies

Yang Xiao-jie○1, Xia Chang-suo2   

  1. 1 Department of Biomedical Engineering, University of Melbourne, Melbourne   3010, Australia; 2 Department of Orthopaedics, Affiliated Hospital of Medical college, Qingdao University, Qingdao   266003, Shandong Province, China
  • Online:2010-02-12 Published:2010-02-12
  • About author:Yang Xiao-jie★, Studying for master’s degree, Department of Biomedical Engineering, University of Melbourne, Melbourne 3010, Australia jesse.modest@hotmail.com

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摘要：

背景：由于缺乏血管和淋巴分布，关节软骨组织的自我修复能力较差。
目的：概述自体软骨细胞移植的研究进展，介绍基质诱导自体软骨细胞移植、内置支架、以及应用于软骨损伤修复的组织工程技术；并对自体软骨细胞移植未来的发展方向做出展望。
方法：以articular cartilage, transplantation, stem cells, tissue engineering为检索词，检索ISI Web of Knowledge，PubMed数据库(1979/2009-02)；以关节软骨、修复、组织工程为检索词，检索CNKI数据库(1979/2009-02)。文献检索语种限制为英文和中文。纳入自体软骨细胞移植、基质诱导的自体软骨细胞移植、内置支架技术和相关组织工程技术的内容。排除关节软骨损伤的医学成像观察、细胞信号转导路径、基因治疗等研究。
结果与结论：计算机初检得到824篇文献。根据纳入排除标准，对自体软骨细胞移植、基质诱导自体软骨移植、内置支架及相关的组织工程技术进行分析。自体软骨细胞移植是过去10年中临床修复关节软骨损伤的最佳方案。近年来，传统的软骨细胞移植出现了很多改进和发展，其中基质诱导自体软骨移植、内置支架技术和相关组织工程技术是目前发展得相对成熟的几个方面，但仍然存在一些亟待解决的问题。基质诱导自体软骨移植目前正在逐步取代传统的自体软骨移植，但其长期效果还需要进一步的临床研究和确认。新的内置支架技术和相关组织工程技术也从材料学、细胞生物学及分子遗传生物学的方向，推动了关节软骨损伤修复的发展。

关键词: 自体软骨细胞移植, 基质诱导, 内置支架, 软骨组织工程, 综述文献

Abstract:

BACKGROUND: Self-repairing capability of articular cartilage tissue is poor, due to lack of the distribution of vessels and lymph.
OBJECTIVE: To concisely describe the research progress of autologous chondrocyte implantation (ACI), including matrix-induced autologous chondrocyte implantation (MACI), in vivo scaffolds, and related tissue engineering technologies, and to prospect the future developments.
METHODS: A search across the databases of ISI Web of Knowledge and PubMed (1979 to February 2009) was performed, with key words of “articular cartilage, transplantation, stem cells, tissue engineering”. As well, a search in the database of CNKI (1979 to Febraruy 2009) was performed with the key words of “articular cartilage, repair, tissue engineering”. Contents referring to ACI, MACI, in vivo scaffolds and related tissue engineering technologies were included, while contents regarding to the clinical imaging of articular cartilage defects, intracellular signaling pathways in chondrocytes, or gene therapy for articular cartilage defects were excluded.
RESULTS AND CONCLUSION: 824 articles were obtained from the preliminary search across the databases. Based on the nominated evaluation criterions to the outcome, analysis focusing on ACI, MACI, in vivo scaffolds and related tissue engineering technologies was performed. As the most successful treatment for articular cartilage defects in the past decade, ACI has undergone a significant development. Recent improvements of ACI include MACI, in vivo scaffolds and related tissue engineering technologies, which exhibit relatively more success in engineering and clinical practice. Nonetheless, limitations still exist and therefore, further researches are required. As a promising alternative of ACI, MACI is more and more widely used in clinical practice for treating articular cartilage defects these years. The long-term curative effect of MACI, however, requires further clinical data to confirm. In addition, other improvements of ACI, in terms of material science, cytology and molecular biology, have been also provided by the developments of in vivo scaffolds and related tissue engineering technologies.

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