中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (2): 528-536.doi: 10.12307/2025.585

• 生物材料相关大数据分析 Big data analysis of biomaterials • 上一篇    

生物材料与骨再生：研究热点及有影响力的500篇文献分析

姜  侃1，2，阿力木江·阿不都肉苏力1，2，沙拉依丁·艾尔西丁1，2，艾克拜尔江·艾赛提1，2，库提鲁克·守克尔1，2，艾克热木江·木合热木1，2   

  1. 新疆医科大学第六附属医院，1骨科，2 骨科再生医学重点实验室，新疆维吾尔自治区乌鲁木齐市   830002
  • 收稿日期:2024-11-06 接受日期:2024-12-31 出版日期:2026-01-18 发布日期:2025-07-03
  • 通讯作者: 艾克热木江·木合热木，博士，主任医师，副教授，硕士生导师，新疆医科大学第六附属医院，骨科，骨科再生医学重点实验室，新疆维吾尔自治区乌鲁木齐市 830002
  • 作者简介:姜侃，男，1971年生，新疆维吾尔自治区乌鲁木齐市人，汉族，副教授，主要从事骨再生相关研究。 阿力木江·阿不都肉苏力，男，2000年生，新疆维吾尔自治区乌鲁木齐市人，新疆医科大学第六附属医院关节外科在读硕士，主要从事骨缺损和骨再生相关研究。

Biomaterials and bone regeneration: research hotspots and analysis of 500 influential papers

Jiang Kan1, 2, Alimujiang·Abudourousuli1, 2, Shalayiding·Aierxiding1, 2, Aikebaierjiang·Aisaiti1, 2, Kutiluke·Shoukeer1, 2, Aikeremujiang·Muheremu1, 2   

  1. 1Department of Orthopedics, 2Key Laboratory of Orthopedic Regenerative Medicine, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China
  • Received:2024-11-06 Accepted:2024-12-31 Online:2026-01-18 Published:2025-07-03
  • Contact: Aikeremujiang · Muheremu, MD, Chief physician, Associate professor, Master’s supervisor, Department of Orthopedics, and Key Laboratory of Orthopedic Regenerative Medicine, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China
  • About author:Jiang Kan, Associate professor, Department of Orthopedics, and Key Laboratory of Orthopedic Regenerative Medicine, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China Alimujiang·Abudourousuli, Master candidate, Department of Orthopedics, and Key Laboratory of Orthopedic Regenerative Medicine, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China

PDF

4

摘要：

文题释义：
骨缺损：是指由于创伤、疾病、肿瘤切除或先天性畸形等原因导致的一部分或全部骨组织缺失，这种情况会损害骨骼的结构完整性和力学功能，通常需要通过外科手术和生物材料的植入来促进骨的修复和再生，以恢复骨的正常形态和功能。
骨再生材料：指那些能够促进骨组织修复和再生的生物相容性材料。骨再生材料模拟自然骨的成分和结构，为骨细胞提供生长环境，通过提供机械支撑和生物活性刺激，加速骨愈合过程，在骨折治疗、骨缺损修复及牙科种植等领域发挥着重要作用。 

背景：新型生物材料不仅提供必要的机械支撑，还能促进细胞增殖和分化、诱导骨再生，从而改善治疗效果，为骨再生技术的发展提供了新的视角和方法。
目的：通过文献计量学方法可视化分析生物材料在骨再生领域的研究状况及发展前景。
方法：在Web of Science核心数据库中，精选了数据库建库至2024-09-24关于骨再生和生物材料领域最具影响力的文献500篇，运用VOSviewer和CiteSpace两款工具进行深入的计量学可视化分析，以揭示该领域的研究趋势和核心文献 
结果与结论：在所选的500篇文献中，中国和美国在发表论文数量和被引用率方面均占据领先地位，而常江是发文最多的作者，发表文章最多的期刊为Acta Biomaterialia。骨再生和材料学是一个跨学科的研究范畴，涵盖了材料科学、生物医学工程、细胞生物学、分子生物学等多个学科领域。骨修复材料的研究正从传统的生物惰性材料向生物活性材料转变，这些材料不仅提供机械支撑，还能促进细胞增殖和分化，诱导骨再生。合成骨修复材料因丰富的来源、可调节的物理化学特性以及较低的免疫排斥和疾病传播风险，正逐渐替代传统材料，成为临床骨移植手术的首选。研究者们正在不断改进这些材料的生物相容性、仿生特性、骨传导性和骨诱导性，使其更接近天然骨，前沿主要集中在生物活性陶瓷、3D打印、水凝胶、壳聚糖、羟基磷灰石等材料。新型材料在骨再生领域中的作用至关重要，随着材料科学技术的不断进步，这些新型材料在骨再生领域的应用前景非常广阔，有望为骨缺损治疗提供更为有效和个性化的治疗方案。
https://orcid.org/0009-0008-6254-4800(阿力木江·阿不都肉苏力)；https://orcid.org/0000-0002-1690-9644(艾克热木江·木合热木)


关键词: 骨再生, 生物材料, 文献计量学, 骨科学, 组织工程, 可视化, Cite space, VOSviewer, 工程化材料

Abstract: BACKGROUND: Novel biomaterials not only provide the necessary mechanical support but also promote cell proliferation and differentiation, inducing bone regeneration, thereby improving therapeutic outcomes and offering new perspectives and methods for the development of bone regenerative technologies.
OBJECTIVE: To visualize the research status and development prospects of biomaterials in the field of bone regeneration through bibliometric methods. 
METHODS: A total of 500 of the most influential papers on bone regeneration and biomaterials were selected from the Web of Science Core Collection database from inception to September 24, 2024. VOSviewer and CiteSpace tools were used for in-depth bibliometric visualization analysis to reveal the research trends and core literature in this field. 
RESULTS AND CONCLUSION: Among the selected 500 papers, China and the United States were in a leading position in terms of the number of published papers and citation rates, with Chang Jiang being the most prolific author and the journal Acta Biomaterialia publishing the most articles. Bone regeneration and material science is an interdisciplinary research field, covering various disciplines including materials science, biomedical engineering, cell biology, and molecular biology. Research on bone repair materials is shifting from traditional bioinert materials to bioactive materials, which not only provide mechanical support but also promote cell proliferation and differentiation, inducing bone regeneration. Synthetic bone repair materials are gradually replacing traditional materials, becoming the preferred choice for clinical bone graft surgery due to their abundant sources, adjustable physicochemical properties, and lower risks of immune rejection and disease transmission. Researchers are continuously improving the biocompatibility, biomimetic properties, osteoconductivity, and osteoinductivity of these materials to make them closer to natural bone. The frontiers are mainly focused on bioactive ceramics, 3D printing, hydrogels, chitosan, hydroxyapatite, and other materials. New materials play a vital role in the field of bone regeneration. With the continuous advancement of materials science and technology, the application prospects of these new materials in the field of bone regeneration are very broad, and they are expected to provide more effective and personalized treatment options for bone defect treatment. 




Key words: bone regeneration, biomaterial, bibliometrics, orthopedics, tissue engineering, visualization, CiteSpace, VOSviewer, engineered material

中图分类号: