中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (35): 7589-7600.doi: 10.12307/2025.752

• 组织构建综述 tissue construction review • 上一篇    下一篇

SOX5在骨代谢和骨病预防中的作用及与运动的相互关系

李志鹏,邢荣鑫,胡亮红   

  1. 广西民族师范学院,广西壮族自治区崇左市  532200
  • 收稿日期:2024-09-07 接受日期:2024-10-26 出版日期:2025-12-18 发布日期:2025-05-07
  • 通讯作者: 胡亮红,硕士,讲师,广西民族师范学院,广西壮族自治区崇左市 532200
  • 作者简介:李志鹏,男,1993年生,湖南省郴州市人,汉族,2018年首都体育学院毕业,硕士,讲师,广西民族师范学院,主要从事运动促进健康方向研究。
  • 基金资助:
    江西省教育厅科技计划重点项目(GJJ170627);广西职业教育教学改革研究项目重点项目(GXGZJG2024A028)

Roles of SOX5 in bone metabolism and prevention of bone diseases and the relationship with exercise#br#
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Li Zhipeng, Xing Rongxin, Hu Lianghong   

  1. Guangxi Normal University for Nationalities, Chongzuo 532200, Guangxi Zhuang Autonomous Region, China
  • Received:2024-09-07 Accepted:2024-10-26 Online:2025-12-18 Published:2025-05-07
  • Contact: Hu Lianghong, MS, Lecturer, Guangxi Normal University for Nationalities, Chongzuo 532200, Guangxi Zhuang Autonomous Region, China
  • About author:Li Zhipeng, MS, Lecturer, Guangxi Normal University for Nationalities, Chongzuo 532200, Guangxi Zhuang Autonomous Region, China
  • Supported by:
    Key Project of Science and Technology Program of Jiangxi Provincial Department of Education, No. GJJ170627; Key Project of Guangxi Vocational Education Teaching Reform Research Project, No. GXGZJG2024A028

摘要:


文题释义:
骨代谢:是指骨组织在生理和病理状态下的形成和破坏过程,主要包括骨生成和骨吸收两个方面。骨生成由成骨细胞负责,主要通过合成骨基质和矿化来形成新骨;而骨吸收则是由破骨细胞进行的,通过分解骨基质和释放矿物质进入血液。骨代谢的平衡对维持骨骼健康至关重要,骨代谢失衡可能导致骨质疏松、骨折等疾病。此外,骨代谢还受到多种因素的影响,包括激素(如甲状旁腺激素、雌激素)、营养(如钙、维生素D)及机械负荷等。
软骨代谢:是指软骨组织在生长、发育和修复过程中,细胞、基质和细胞外基质的合成与降解的动态平衡过程。软骨主要由软骨细胞(成软骨细胞)、细胞外基质(如胶原蛋白、蛋白多糖和水)组成,负责支撑关节、减轻冲击和提供滑动表面。在软骨代谢中,软骨细胞通过合成和分泌基质成分来维持软骨的结构和功能。与此同时,酶(如基质金属蛋白酶)介导的降解过程确保旧的或损伤的基质可以被清除。正常的软骨代谢对于关节的健康至关重要,软骨代谢失衡可能导致软骨退化、关节炎等疾病。

背景:SOX5是SOX(SRY-related HMG-box)家族的重要转录因子,通过其特有的HMG盒DNA结构域协同SOX6和SOX9,在调控骨发育和重塑相关基因表达中起关键作用,特别是在成骨细胞分化和软骨细胞成熟过程中。此外,SOX5及其家族的表达和活性受多种疾病和不同形式的运动等因素调控,这表明SOX5及其家族未来有可能作为药物和治疗手段有效改善相关疾病。
目的:为未来关于SOX5的研究提供新视角,并为运动干预和药物治疗在骨病预防和治疗中的应用提供科学依据。
方法:检索中国知网和PubMed数据库,以“SRY-related HMG-box5,SOX5,Bone”为英文检索词,以“SRY- box转录因子5,SOX5,骨”为中文检索词,检索2001年至2024年6月发表的所有相关文献,并对其进行筛选、归纳、分析、总结,最后纳入105篇文献进行综述。
结果与结论:①SOX5 在骨发育中的作用:SOX5是SOX家族的重要成员,在调控骨骼发育、骨代谢和软骨形成中发挥核心作用。与 SOX6和SOX9协同,SOX5通过结合特定DNA序列,激活成骨细胞和软骨细胞的基因表达,调控骨形成和骨重塑过程。②SOX5的异常表达与骨关节疾病如软骨发育不良、骨质疏松和骨关节炎等密切相关,表明它可能是这些疾病的关键调控因子,目前多种药物可能是通过调节SOX5及其家族来治疗骨代谢相关疾病,在骨组织工程中,上调间充质干细胞中SOX5可能有效改善骨代谢疾病患者的症状。③运动可以通过增强骨代谢,促进成骨细胞分化和骨密度增加,从而有效预防骨质疏松和相关骨疾病。这种作用机制可能与SOX5的具体调控机制有关,尤其是在不同类型、强度和持续时间的运动需要进一步探索研究。综上,SOX5在骨发育、软骨形成以及骨病预防中具有重要的调控作用,其活性受到多种因素的调控,而运动干预为骨病的治疗提供了新的科学依据。
https://orcid.org/0009-0000-9666-6787(李志鹏)

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

关键词: SOX5, 转录因子, 软骨发育, 炎症, 骨骼重塑, 骨代谢, 运动

Abstract: BACKGROUND: SOX5 is an important transcription factor of the SRY-related HMG-box (SOX) family, which plays a key role in regulating the expression of genes related to bone development and remodeling, especially during osteoblast differentiation and chondrocyte maturation, through its unique HMG box DNA structural domains in concert with SOX6 and SOX9. In addition, the expression and activity of SOX5 and its family are regulated by a variety of diseases and different forms of exercise, among other factors, suggesting that SOX5 and its family have the potential to be effective as drugs and therapeutics to ameliorate related diseases in the future.
OBJECTIVE: To provide new perspectives for future research on SOX5 and to provide scientific basis for the application of exercise intervention and drug therapy in the prevention and treatment of bone diseases.
METHODS: CNKI and PubMed databases were searched for relevant literature published from 2001 to June 2024, and the search terms were “SRY-related HMG-box5, SOX5, Bone” in Chinese and English, respectively. After screening, analysis and summarization, 105 articles were included in the final review.
RESULTS AND CONCLUSION: (1) Role of SOX5 in bone development: SOX5 is an important member of the SOX family, which plays a central role in the regulation of skeletal development, bone metabolism and cartilage formation. In synergy with SOX6 and SOX9, SOX5 activates gene expression in osteoblasts and chondrocytes by binding to specific DNA sequences to regulate bone formation and bone remodeling. (2) Abnormal expression of SOX5 is closely related to bone and joint diseases such as chondrodysplasia, osteoporosis and osteoarthritis, suggesting that it may be a key regulator of these diseases. Currently, a variety of drugs may be used to treat bone metabolism-related diseases by regulating SOX5 and its family, and upregulation of SOX5 in mesenchymal stem cells may be effective in improving the symptoms of bone metabolism disease patients in bone tissue engineering. (3) Exercise may effectively prevent osteoporosis and related bone diseases by enhancing bone metabolism and promoting osteoblast differentiation and bone density increase. This mechanism of action may be related to the specific regulatory mechanism of SOX5, especially in different types, intensities and durations of exercise need to be further explored and studied. In conclusion, SOX5 has an important regulatory role in bone development, chondrogenesis, and prevention of bone diseases, and its activity is regulated by a variety of factors, while exercise intervention provides a new scientific basis for the treatment of bone diseases.

Key words: SOX5, transcription factor, chondrogenesis, inflammation, bone remodeling, bone metabolism, exercise

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