中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (24): 5203-5211.doi: 10.12307/2025.792

• 组织构建循证医学 evidence-based medicine in tissue construction • 上一篇    下一篇

运动干预脑卒中患者心肺功能的Meta分析

邓依然1，王先亮1，李丹丹2   

  1. 1山东大学体育学院，山东省济南市  250061；2济南大学教育与心理科学学院，山东省济南市  250022


  • 收稿日期:2024-08-05 接受日期:2024-10-25 出版日期:2025-08-28 发布日期:2025-02-05
  • 通讯作者: 王先亮，博士，研究员，博士生导师，山东大学体育学院，山东省济南市 250061
  • 作者简介:邓依然，男，1998年生，山东省济宁市人，汉族，山东大学体育学院在读硕士，主要从事运动训练与运动康复研究。
  • 基金资助:
    国家重点研发计划(2020YFC2006804)，项目负责人：王先亮

Meta-analysis of exercise intervention on cardiopulmonary function in stroke patients

Deng Yiran1, Wang Xianliang1, Li Dandan2   

  1. 1School of Physical Education, Shandong University, Jinan 250061, Shandong Province, China; 2School of Education and Psychology, University of Jinan, Jinan 250022, Shandong Province, China
  • Received:2024-08-05 Accepted:2024-10-25 Online:2025-08-28 Published:2025-02-05
  • Contact: Wang Xianliang, PhD, Research fellow, Doctoral supervisor, School of Physical Education, Shandong University, Jinan 250061, Shandong Province, China
  • About author:Deng Yiran, Master candidate, School of Physical Education, Shandong University, Jinan 250061, Shandong Province, China
  • Supported by:
    National Key Research and Development Program of China, No. 2020YFC2006804 (to WXL)

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摘要：


文题释义：
脑卒中：俗称中风，是由多种原因导致脑血管受损、产生局灶性或整体脑组织损害的疾病。
心肺功能：即人体心脏泵血及肺部吸入氧气的能力，直接影响全身器官及肌肉的活动。

摘要
目的：临床上脑卒中患者在康复期间会经历显著的心肺功能障碍，这增加了复发性脑卒中的概率，而通过运动干预则可以有效改善脑卒中患者的心肺功能。此文通过Meta分析方法对国内外关于运动干预改善脑卒中患者心肺功能的研究进行综合定量评价，检验不同运动方式对脑卒中患者心肺功能的影响，探索最佳运动方案。
方法：检索中国知网、万方、维普、Web of Science、Cochrane图书馆、PubMed、EBSCO数据库建库至2024-05-15发表的相关文章，主要纳入运动干预改善脑卒中患者心肺功能的随机对照试验，采用Review Manager 5.4和Stata 17软件进行统计分析。
结果：①共纳入符合标准的文献32篇，包括脑卒中患者1 826例；②结果显示，运动干预能够显著改善脑卒中患者的摄氧能力[MD=2.10，95%CI(1.57，2.63)，P < 0.000 01]，采用高强度间歇训练的干预方式，每周干预五六次，每次干预41-60 min，持续干预12周以上是改善脑卒中患者摄氧能力的最佳运动方案；③运动干预可以明显提高脑卒中患者有氧运动耐力[MD=38.00，95%CI(29.55，46.45)，P < 0.000 01]，采用高强度间歇训练的干预方式，每周干预两三次，每次干预41-60 min，持续干预12周以上是改善脑卒中患者有氧运动耐力的最佳运动方案。
结论：运动干预可以显著改善脑卒中患者心肺功能，高强度间歇训练是最具潜力的运动干预方式。所以采用高强度间歇训练，每次干预41-60 min，初始干预频率每周2次，根据耐受情况逐渐增加干预频率，并持续干预12周以上是改善脑卒中患者心肺功能的最佳运动方案；未来应收集更多高质量、多项目的临床研究和证据来验证上述结论，尤其是探索高强度间歇训练改善脑卒中患者心肺功能的最佳运动——间歇比值。
https://orcid.org/0009-0009-8263-3410(邓依然)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 脑卒中, 心肺功能, 运动干预, Meta分析, 随机对照试验, 系统评价, 最佳运动方案, 功能恢复, 运动生理, 工程化组织构建

Abstract: OBJECTIVE: Clinically, stroke patients experience significant cardiopulmonary dysfunction during rehabilitation, which increases the likelihood of recurrent stroke. However, exercise interventions can effectively improve cardiopulmonary function in stroke patients. This paper employs meta-analysis to conduct a comprehensive quantitative evaluation of domestic and international studies on the improvement of cardiopulmonary function in stroke patients through exercise interventions. It examines the effects of different exercise modalities on the cardiopulmonary function of stroke patients and explores the optimal exercise regimen.
METHODS: China National Knowledge Infrastructure (CNKI), WanFang Data, VIP, Web of Science, Cochrane Library, PubMed, and EBSCO databases were searched for articles published from inception to May 15, 2024, primarily including randomized controlled trials on exercise interventions improving cardiopulmonary function in stroke patients. Statistical analyses were conducted using Review Manager 5.4 and Stata 17 software.
RESULTS: (1) A total of 32 articles meeting the criteria were included, involving 1 826 stroke patients. (2) The results showed that exercise interventions significantly improved the oxygen uptake capacity of stroke patients [MD=2.10, 95%CI(1.57,2.63), P < 0.000 01]. The optimal exercise regimen for improving oxygen uptake capacity was high-intensity interval training, conducted 5-6 times per week, with each session lasting 41-60 minutes, for a duration of more than 12 weeks. (3) Exercise interventions also significantly enhanced the aerobic endurance of stroke patients [MD=38.00, 95%CI(29.55,46.45), P < 0.000 01]. The optimal regimen for improving aerobic endurance was high-intensity interval training, conducted 2-3 times per week, with each session lasting 41-60 minutes, for a duration of more than 12 weeks.
CONCLUSION: Exercise interventions can significantly improve the cardiopulmonary function of stroke patients, with high-intensity interval training being the most promising exercise modality. Therefore, the optimal exercise regimen for improving cardiopulmonary function in stroke patients is to conduct high-intensity interval training sessions lasting 41-60 minutes, starting with an intervention frequency of twice a week, gradually increasing the frequency based on tolerance, and continuing the intervention for more than 12 weeks. Future research should focus on collecting more high-quality, multi-faceted clinical studies and evidence to validate these conclusions, particularly in exploring the optimal exercise-to-rest ratio of high-intensity interval training for improving cardiopulmonary function in stroke patients.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: stroke, cardiopulmonary function, exercise intervention, meta-analysis, randomized controlled trial, systematic review, optimal exercise regimen, functional recovery, exercise physiology, engineered tissue construction

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