中国组织工程研究

中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (34): 5523-5530.doi: 10.3969/j.issn.2095-4344.1970

• 生物材料综述 biomaterial review • 上一篇    下一篇

组织工程研究中的电活性生物材料

熊  莹1，许  燕1，周建平1，张旭婧1，王恪典1，2
  

  1. 1新疆大学机械工程学院，新疆维吾尔自治区乌鲁木齐市  830047；2西安交通大学机械工程学院，陕西省西安市  710049
  • 收稿日期:2019-06-20 出版日期:2019-12-08 发布日期:2019-12-08
  • 通讯作者: 王恪典，教授，博士生导师，新疆大学机械工程学院，新疆维吾尔自治区乌鲁木齐市 830047；西安交通大学机械工程学院，陕西省西安市 710049
  • 作者简介:熊莹，女，1994年生，女，新疆维吾尔自治区博乐市人，硕士，主要从事组织工程骨支架制备与性能研究。
  • 基金资助:

    新疆维吾尔自治区自然科学基金资助项目(2017D01C021)，项目负责人：许燕

Electroactive biomaterials in tissue engineering research

Xiong Ying1, Xu Yan1, Zhou Jianping1, Zhang Xujing1, Wang Kedian1, 2
  

  1. 1School of Mechanical Engineering, Xinjiang University, Urumqi 830047, Xinjiang Uygur Autonomous Region, China; 2School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, Shaanxi Province, China
     
  • Received:2019-06-20 Online:2019-12-08 Published:2019-12-08
  • Contact: Wang Kedian, Professor, Doctoral supervisor, School of Mechanical Engineering, Xinjiang University, Urumqi 830047, Xinjiang Uygur Autonomous Region, China; School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, Shaanxi Province, China
  • About author:Xiong Ying, Master, School of Mechanical Engineering, Xinjiang University, Urumqi 830047, Xinjiang Uygur Autonomous Region, China
  • Supported by:

    the Natural Science Foundation of Xinjiang Uygur Autonomic Region, No. 2017D01C021 (to XY)

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摘要：

文章快速阅读：

 

文题释义：
电活性生物材料：在电信号作用下能改变理化性质或在外界刺激作用下能产生电信号的一类生物医学材料的总称。
组织工程：是应用医学、生物学和工程学等专业知识，研究并开发能在结构和功能上模拟人体组织或器官的生物活性替代物的一门科学。包含细胞、支架及生长信号这3个要素。其中，细胞是一切生物组织最基本的结构单位；而支架是用于支撑细胞成长为一个完整的组织的框架材料；生长信号则是用于引导和协调组织内细胞活动的各种方法，目前已知的能影响细胞活动的生长信息包括各种蛋白质因子和电信号。
 
 
背景：多项研究证明人体组织与生物电有着密切的联系，因此深入研究材料在细胞和组织电学微环境建立方面的研究是实现缺损组织完美修复与再生的突破点。
目的：综述电活性生物材料在组织工程研究领域的应用。
方法：利用计算机检索Wiley Online Library、Web of Science、CNKI及万方数据库2006年1月至2019年3月期间发表的关于电活性生物材料(导电聚合物，压电材料，碳基材料)在组织工程研究及应用中的文章。中文检索词为“电活性生物材料，导电聚合物，压电材料，碳基材料，组织工程”，对应的英文检索词为“electroactive biomaterials，composite materials，piezoelectric materials，carbon-based materials，tissue engineering”。
结果与结论：电活性生物材料具备一定的生物相容性及良好的信号传导能力，可弥补现今生物材料在调控细胞分化和组织再生方面的缺陷，在组织工程领域具有良好的应用前景，但其存在诸如降解性能较差、力学性能欠佳等缺点，制约了其应用。因此需充分掌握电活性生物材料的特性及优缺点，才能使之最大限度地仿生天然组织的结构和功能，为细胞分化和组织再生提供良好的电生理微环境，最终智能地调控细胞分化与组织再生。

关键词: 电活性生物材料, 导电聚合物, 压电材料, 碳基材料, 复合材料, 组织工程, 再生医学, 支架材料

Abstract:

BACKGROUND: Several studies have shown that human tissue is closely related to bioelectricity. Therefore, in-depth research on the establishment of cell and tissue electrical microenvironment of materials is a breakthrough for achieving perfect repair and regeneration of defective tissues.
OBJECTIVE: To summarize the application of electroactive biomaterials in tissue engineering.
METHODS: Wiley Online Library, Web of Science, CNKI and Wanfang database were searched to retrieve papers addressing on the research and application of electroactive biomaterials (conductive polymers, piezoelectric materials and carbon-based materials) in tissue engineering published from January 2006 to March 2019. The search terms were "electroactive biomaterials, conductive polymers, piezoelectric materials, carbon-based materials, tissue engineering" in Chinese and “electroactive biomaterials, composite materials, piezoelectric materials, carbon-based materials, tissue engineering” in English.
RESULTS AND CONCLUSION: Electroactive biomaterials possess certain biocompatibility, excellent mechanical properties and signal transmission ability, which can make up for the shortcomings of current biomaterials in regulating cell differentiation and tissue regeneration. So it has a good application prospect in the field of tissue engineering. However, it has some disadvantages such as poor degradation performance and poor mechanical property, which restrict its application. Therefore, it is necessary to fully grasp the characteristics of electroactive biological materials and their advantages and disadvantages, so as to produce the structure and function to the largest extent similar to those of natural tissues, which provide a good electrophysiological microenvironment for cell differentiation and tissue regeneration, and finally intelligently regulate cell differentiation and tissue regeneration.

Key words: electroactive biomaterials, conductive polymers, piezoelectric materials, carbon-based materials, composite materials, tissue engineering, regenerative medicine, scaffold material

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