中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (30): 4524-4531.doi: 10.3969/j.issn.2095-4344.2016.30.017

• 生物材料综述 biomaterial review • 上一篇    下一篇

吗啉-2,5-二酮及其衍生物:有价值的生物降解聚合物材料

周群华1,杨立群2,张 巍2,李 淼2   

  1. 1郑州澍青医学高等专科学校,河南省郑州市 450064;2辽宁省计划生育科学研究院,国家卫生和计划生育委员会生殖健康与遗传医学重点实验室,辽宁省沈阳市 110031
  • 收稿日期:2016-05-30 出版日期:2016-07-15 发布日期:2016-07-15
  • 通讯作者: 杨立群,1982年生,副研究员,辽宁省计划生育科学研究院,国家卫生和计划生育委员会生殖健康与遗传医学重点实验室,辽宁省沈阳市 110031
  • 作者简介:周群华,女,河南郑州市人,讲师,主要从事生物医药高分子材料和有机化学合成研究。
  • 基金资助:

    国家自然科学基金(51503093);辽宁省科学事业公益研究基金(2015001007);辽宁省博士科研启动基金(201501116);沈阳市科技攻关项目(F16-205-1-37)

Morpholine-2, 5-dione and its derivatives: the valuable biodegradable polymer materials

Zhou Qun-hua1, Yang Li-qun2, Zhang Wei2, Li Miao2   

  1. 1Zhengzhou Shuqing Medical College, Zhengzhou 450064, Henan Province, China; 2Liaoning Provincial Family Planning Research Institute, Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, Shenyang 110031, Liaoning Province, China
  • Received:2016-05-30 Online:2016-07-15 Published:2016-07-15
  • Contact: Yang Li-qun, Associate researcher, Liaoning Provincial Family Planning Research Institute, Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, Shenyang 110031, Liaoning Province, China
  • About author:Zhou Qun-hua, Lecturer, Zhengzhou Shuqing Medical College, Zhengzhou 450064, Henan Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 51503093; the Science Public Research Foundation of Liaoning Province, No. 2015001007; the Doctoral Scientific Research Foundation of Liaoning Province, No. 201501116; the Scientific Research Project of Shenyang, China, No. F16-205-1-37

摘要:

文题释义:
生物降解高分子材料
:又叫生物可吸收高分子材料,是指在一定时间和一定条件下,能被真菌、细菌、藻类、霉菌等微生物在酶的作用下发生降解,使高分子链逐渐断裂的高分子材料,降解产物一般是小分子或低聚物,而这些降解产物一般对生物体无毒,通过吸收或经代谢排出,不会对人体造成伤害。
吗啉-2,5-二酮及其衍生物:是靠酯键和酰胺键构成的一种六元环状单体,它们的均聚物及与其他生物材料的共聚物都是一种有价值的生物可降解医用材料。由于聚合物分子中酰胺键之间能形成氢键,使此材料具有良好的机械性能和热性能,而主链上的酯键易水解,使聚合物具有可降解性能。


背景:生物降解性合成高分子材料在生物医学中目前常被用于神经导管、组织工程、药物控释载体等,而聚吗啉-2,5-二酮及其衍生物目前被广泛应用,其合成方法成为目前研究的热点。
目的:论述吗啉-2,5-二酮及其衍生物单体和聚合物的合成方法,探讨其存在的优势与缺憾。
方法:由第一作者用计算机检索万方数据库、中国知网、Sci和PubMed数据库1982至2015年的文献,检索词为“吗啉-2,5-二酮、生物降解、Morpholine-2,5-dione、Biodegradable”。
结果与结论:吗啉-2,5-二酮及其衍生物单体的合成方法目前主要有:α-氨基酸和α-卤素酰卤的酰化反应、分子内的酯化反应及分子内的缩合反应。各有优缺点,需要探索出一种较为完善的方法。吗啉-2,5-二酮的开环聚合是一种合成聚酯-酰胺的较好的方法,但聚合物的分子量和转化率较低。催化聚合吗啉二酮时目前有金属化合物催化聚合、酶催化聚合。聚吗啉-2,5-二酮是一种非常有价值的可合成的生物降解聚合物材料,目前已被广泛应用于医药领域。

ORCID: 0000-0002-3786-8458(杨立群)

关键词: 生物材料, 缓释材料, 吗啉-2, 5-二酮, 均聚物, 聚合, 生物降解, 酰化反应, 国家自然科学基金

Abstract:

BACKGROUND: Currently, biodegradable polymer materials such as poly(morpholine-2, 5-dione) and its derivatives have been widely used in biomedical field to fabricate nerve catheters, tissue engineering and drug control release carriers. Therefore, many research has focused on the synthesis of poly(morpholine-2, 5-dione) and its derivatives.
OBJECTIVE: To review the synthesis methods of monomeric and polymeric morpholine-2, 5-dione and its derivatives, and to explore its advantages and shortcomings.
METHODS: A computer-based search of databases of Wanfang, CNKI, SCI and PubMed was performed for relevant articles published from 1982 to 2015. And the keywords were “morpholine-2, 5-dion, biodegradable” in Chinese and English, respectively.
RESULTS AND CONCLUSION: So far, acylation reactions of α-amino acids and α-halogen halide, the intramolecular esterifications and intramolecular condensation reactions are the key methods for the synthesis of morpholine-2, 5-dione and its derivatives. A modified approach is needed to overcome the existed disadvantages. Ring-opening polymerization of morpholine-2, 5-dione is a preferred method of synthetic polyester-amide, but low molecular weight and conversion of polymers are produced. Polymerization catalyzed via metal compounds and enzymes are the best strategy for the synthesis of poly(morpholine-2, 5-dione). Furthermore, as a valuable biodegradable polymer material, poly(morpholine-2, 5-dione) has been extensively applied in the medical field.

Key words: Morpholines, Polymerization, Tissue Engineering

中图分类号: