中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (25): 6643-6653.doi: 10.12307/2026.291

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    

股骨头坏死动物模型研究的文献可视化分析

白若琨，莫  坚，韩  杰，李坤健，聂夏裕，陈  帅   

  1. 广西中医药大学附属瑞康医院骨科，广西壮族自治区南宁市   530011
  • 收稿日期:2025-10-15 修回日期:2025-12-21 出版日期:2026-09-08 发布日期:2026-04-23
  • 通讯作者: 莫坚，在读博士，主任医师，硕士生导师，广西中医药大学附属瑞康医院骨科，广西壮族自治区南宁市 530011
  • 作者简介:白若琨，男，1999年生，河北省秦皇岛市人，汉族，广西中医药大学在读硕士，主要从事骨关节疾病中医防治方面的研究。
  • 基金资助:
    广西自然科学基金项目(面上项目)(2024GXNSFAA010370)：三七总皂苷通过OPG干预VWF/RANKL信号通路改善酒精性股骨头坏死骨丢失与微血管凝血的作用机制研究(中医药壮瑶医药联合专项)，项目负责人：莫坚；国家自然科学基金项目(82260858)：骨坚散通过miR-206调控HIF-1α/VEGF、BNIP3信号通路干预激素性股骨头坏死自噬与骨微血管分化机制研究，项目负责人：韩杰

Visualization analysis on research literature about animal models for osteonecrosis of the femoral head

Bai Ruokun, Mo Jian, Han Jie, Li Kunjian, Nie Xiayu, Chen Shuai   

  1. Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
  • Received:2025-10-15 Revised:2025-12-21 Online:2026-09-08 Published:2026-04-23
  • Contact: Mo Jian, MD candidate, Chief physician, Master's supervisor, Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
  • About author:Bai Ruokun, MS candidate, Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
  • Supported by:
    Guangxi Natural Science Foundation Project (General Program), No. 2024GXNSFAA010370 (to MJ); National Natural Science Foundation of China, No. 82260858 (to HJ)

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摘要：



文题释义：
股骨头坏死：是一种骨科疾病，由于股骨头血液供应遭到破坏或中断，导致骨细胞死亡。随后，股骨头结构发生改变，甚至出现塌陷，最终引起髋关节疼痛和功能障碍，它是临床上常见的致残性疾病之一。
动物模型：是指在生物医学研究中，用于模拟人类生理、病理过程或疾病状态的实验动物。其核心目的是通过在可控条件下对动物进行干预和研究，来推断和理解相应人类生命现象的发生机制、发展规律，并用于评估药物、疗法或技术的有效性与安全性。

背景：股骨头坏死是一种以骨细胞凋亡和股骨头结构塌陷为特征的难治性疾病，其发病机制与血管损伤、骨代谢失衡及机械应力异常密切相关。近年来，动物模型作为模拟疾病病理进程的核心工具，在揭示股骨头坏死分子机制、评估新型干预策略中发挥了不可替代的作用，但模型构建的标准化与临床转化价值仍需系统性探讨。
目的：通过文献计量学方法分析股骨头坏死领域的研究现状，重点评价动物模型在研究设计中的应用特点、局限性及未来优化方向，为深化疾病机制理解与治疗开发提供参考。
方法：基于Web of Science核心数据库SCI-Expanded，以“TS=(osteonecrosis of the femoral head) AND TS=(mouse OR mice OR rat OR rabbit OR dog OR swine OR pig OR sheep OR monkey OR “laboratory animal” OR “experiment animal”)”为检索式，筛选2015年1月至2025年3月收录的文献。同时在中国知网+万方数据库中，以“SU=股骨头坏死 AND SU=鼠+兔+犬+猪+羊+猴+实验动物+动物实验”为检索式，筛选2015年1月至2025年3月收录的文献。利用Citespace 6.3.R1软件对纳入的中英文文献的发文国家、机构、作者、关键词及共被引文献进行可视化分析，结合动物模型分类与应用特征归纳研究趋势。
结果与结论：①英文文献中，中国贡献逾八成研究(458篇)；热点聚焦于激素性坏死机制(如氧化应激-自噬轴)、干细胞/组织工程治疗及中药干预；研究表明股骨头坏死动物模型研究呈现“高产出-弱协作”特征；②中文文献里，发文机构以中医药相关机构为主，中药和激素性股骨头坏死是该领域发文的重要热点；③未来需深化跨物种验证平台、多组学整合及中西药发展协同策略，以加速临床转化。

https://orcid.org/0009-0007-3769-0083 (白若琨) 


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 股骨头坏死, 动物模型, 文献计量学, Citespace, 病理机制, 流行病学

Abstract: BACKGROUND: Osteonecrosis of the femoral head is a refractory disorder characterized by osteocyte apoptosis and structural collapse of the femoral head. Its pathogenesis is closely associated with vascular injury, dysregulated bone metabolism, and aberrant mechanical stress. In recent years, animal models have served as indispensable tools for simulating pathological processes, playing an irreplaceable role in elucidating molecular mechanisms of osteonecrosis of the femoral head and evaluating novel interventions. Nevertheless, the standardization of model development and their clinical translational value require systematic investigation.
OBJECTIVE: To analyze the research landscape in the field of osteonecrosis of the femoral head using bibliometric approaches, with an emphasis on evaluating the application characteristics, limitations, and future optimization directions of animal models in study design, providing a reference for advancing mechanistic understanding and therapeutic development.
METHODS: Literature published between January 2015 and March 2025 was retrieved from the Web of Science Core Collection (SCI-Expanded) using the search strategy: TS=(osteonecrosis of the femoral head) AND TS=(mouse OR mice OR rat OR rabbit OR dog OR swine OR pig OR sheep OR monkey OR “laboratory animal” OR “experiment animal”). Simultaneously, Chinese literature was screened from CNKI and WanFang databases (January 2015–March 2025) with the query: SU=(osteonecrosis of the femoral head) AND SU=(mouse OR mice OR rat OR rabbit OR dog OR swine OR pig OR sheep OR monkey OR “laboratory animal” OR “experiment animal”). CiteSpace 6.3.R1 software was employed to visualize publication countries, institutions, authors, keywords, and co-cited references. Research trends were synthesized by integrating animal model classifications and application features.
RESULTS AND CONCLUSION: (1) Among English publications, China contributed over 80% of studies (n=458). Research hotspots focused on steroid-induced necrosis mechanisms (e.g., oxidative stress-autophagy axis), stem cell/tissue engineering therapies, and traditional Chinese medicine interventions. Analysis revealed that osteonecrosis of the femoral head animal model research exhibits a “high output–weak collaboration” pattern. (2) In Chinese literature, traditional Chinese medicine-related institutions dominated publications, with traditional Chinese medicine interventions and steroid-induced osteonecrosis of the femoral head representing major research foci. (3) Future efforts should prioritize cross-species validation platforms, multi-omics integration, and synergistic development strategies for Chinese and Western medicines to accelerate clinical translation.


Key words: osteonecrosis of the femoral head, animal models, bibliometrics, CiteSpace, pathological mechanisms, epidemiology

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