[1] CAO Y, RUAN J, KANG J, et al. Extracellular Vesicles in Infrapatellar Fat Pad from Osteoarthritis Patients Impair Cartilage Metabolism and Induce Senescence. Adv Sci (Weinh). 2024;11(3):e2303614.
[2] PARTRIDGE L, DEELEN J, SLAGBOOM PE. Facing up to the global challenges of ageing. Nature. 2018;561(7721):45-56.
[3] BEHR LC, SIMM A, KLUTTIG A, et al. 60 years of healthy aging: On definitions, biomarkers, scores and challenges. Ageing Res Rev. 2023;88:101934.
[4] REID IR. A broader strategy for osteoporosis interventions. Nat Rev Endocrinol. 2020;16(6):333-339.
[5] BONE HG, WAGMAN RB, BRANDI ML, et al. 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol. 2017;5(7): 513-523.
[6] BLACK DM, ROSEN CJ. Clinical Practice. Postmenopausal Osteoporosis. N Engl J Med. 2016;374(3):254-262.
[7] AREECKAL AS, KOCHER M, S SD. Current and Emerging Diagnostic Imaging-Based Techniques for Assessment of Osteoporosis and Fracture Risk. IEEE Rev Biomed Eng. 2019;12:254-268.
[8] QIN L, LIU W, CAO H, et al. Molecular mechanosensors in osteocytes. Bone Res. 2020;8:23.
[9] BUNPETCH V, ZHANG ZY, ZHANG X, et al. Strategies for MSC expansion and MSC-based microtissue for bone regeneration. Biomaterials. 2019;196:67-79.
[10] KIERNAN J, DAVIES JE, STANFORD WL. Concise Review: Musculoskeletal Stem Cells to Treat Age-Related Osteoporosis. Stem Cells Transl Med. 2017;6(10):1930-1939.
[11] WANG Z, GOH J, DAS DE S, et al. Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model. Tissue Eng. 2006;12(7): 1753-1761.
[12] HAN W, YU Y, LIU XY. Local signals in stem cell-based bone marrow regeneration. Cell Res. 2006;16(2):189-195.
[13] LI F, ZHOU C, XU L, et al. Effect of Stem Cell Therapy on Bone Mineral Density: A Meta-Analysis of Preclinical Studies in Animal Models of Osteoporosis. PLoS One. 2016;11(2):e0149400.
[14] KALLURI R, LEBLEU VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977.
[15] MATHIEU M, MARTIN-JAULAR L, LAVIEU G, et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21(1):9-17.
[16] REN R, TAN XH, ZHAO JH, et al. Bone marrow mesenchymal stem cell-derived exosome uptake and retrograde transport can occur at peripheral nerve endings. Artif Cells Nanomed Biotechnol. 2019; 47(1):2918-2929.
[17] YING C, WANG R, WANG Z, et al. BMSC-Exosomes Carry Mutant HIF-1α for Improving Angiogenesis and Osteogenesis in Critical-Sized Calvarial Defects. Front Bioeng Biotechnol. 2020;8:565561.
[18] BEI HP, HUNG PM, YEUNG HL, et al. Bone-a-Petite: Engineering Exosomes towards Bone, Osteochondral, and Cartilage Repair. Small. 2021;17(50):e2101741.
[19] YANG D, ZHANG W, ZHANG H, et al. Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics. Theranostics. 2020;10(8):3684-3707.
[20] YU W, HURLEY J, ROBERTS D, et al. Exosome-based liquid biopsies in cancer: opportunities and challenges. Ann Oncol. 2021;32(4):466-477.
[21] FAFIÁN-LABORA JA, RODRÍGUEZ-NAVARRO JA, O’LOGHLEN A. Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage. Cell Metab. 2020;32(1):71-86.e5.
[22] ZHANG S, CHUAH SJ, LAI RC, et al. MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity. Biomaterials. 2018;156:16-27.
[23] ZHOU B, XU K, ZHENG X, et al. Application of exosomes as liquid biopsy in clinical diagnosis. Signal Transduct Target Ther. 2020;5(1):144.
[24] HU N, CAI Z, JIANG X, et al. Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing. Acta Biomater. 2023;157:175-186.
[25] RUAN Y, KATO H, TAGUCHI Y, et al. Irradiation by high-intensity red light-emitting diode enhances human bone marrow mesenchymal stem cells osteogenic differentiation and mineralization through Wnt/β-catenin signaling pathway. Lasers Med Sci. 2021;36(1):55-65.
[26] BHUJEL B, SHIN HE, CHOI DJ, et al. Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review. Int J Mol Sci. 2022;23(13):7306.
[27] AGUAYO-MAZZUCATO C, ANDLE J, LEE TB JR, et al. Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes. Cell Metab. 2019;30(1):129-142.e4.
[28] JIN S, WANG Y, WU X, et al. Young Exosome Bio-Nanoparticles Restore Aging-Impaired Tendon Stem/Progenitor Cell Function and Reparative Capacity. Adv Mater. 2023;35(18):e2211602.
[29] XIAO Y, XIE X, CHEN Z, et al. Advances in the roles of ATF4 in osteoporosis. Biomed Pharmacother. 2023;169:115864.
[30] MORA-RAIMUNDO P, LOZANO D, MANZANO M, et al. Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment. ACS Nano. 2019; 13(5):5451-5464.
[31] HU Y, TIAN H, CHEN W, et al. The Critical Role of The Piezo1/β-catenin/ATF4 Axis on The Stemness of Gli1+ BMSCs During Simulated Microgravity-Induced Bone Loss. Adv Sci (Weinh). 2023; 10(32):e2303375.
[32] ANKRUM JA, ONG JF, KARP JM. Mesenchymal stem cells: immune evasive, not immune privileged. Nat Biotechnol. 2014;32(3):252-260.
[33] ROMBOUTS WJ, PLOEMACHER RE. Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture. Leukemia. 2003;17(1):160-170.
[34] YÁÑEZ-MÓ M, SILJANDER PR, ANDREU Z, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4:27066.
[35] THÉRY C, WITWER KW, AIKAWA E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750.
[36] WITWER KW, THÉRY C. Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature. J Extracell Vesicles. 2019; 8(1):1648167.
[37] ZHA Y, LI Y, LIN T, et al. Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects. Theranostics. 2021;11(1):397-409.
[38] HAN C, SUN X, LIU L, et al. Exosomes and Their Therapeutic Potentials of Stem Cells. Stem Cells Int. 2016;2016:7653489.
[39] WU J, KUANG L, CHEN C, et al. miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis. Biomaterials. 2019;206:87-100.
[40] JIANG YL, WANG ZX, LIU XX, et al. The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer’s Disease Diminished with Aging. Adv Sci (Weinh). 2022;9(17):e2105316.
[41] PLAKHOVA N, PANAGOPOULOS V, VANDYKE K, et al. Mesenchymal stromal cell senescence in haematological malignancies. Cancer Metastasis Rev. 2023; 42(1):277-296.
[42] BRUDER SP, JAISWAL N, HAYNESWORTH SE. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem. 1997;64(2):278-294.
[43] YANG YK, OGANDO CR, WANG SEE C, et al. Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro. Stem Cell Res Ther. 2018;9(1):131.
[44] THIND A, WILSON C. Exosomal miRNAs as cancer biomarkers and therapeutic targets. J Extracell Vesicles. 2016;5:31292.
[45] QIU M, ZHAI S, FU Q, et al. Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MicroRNA-150-3p Promotes Osteoblast Proliferation and Differentiation in Osteoporosis. Hum Gene Ther. 2021;32(13-14):717-729.
[46] YANG X, YANG J, LEI P, et al. LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c/SATB2 axis. Aging (Albany NY). 2019;11(20):8777-8791.
[47] GONZÁLEZ A, HALL MN, LIN SC, et al. AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control. Cell Metab. 2020;31(3):472-492. |