中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (35): 7649-7655.doi: 10.12307/2025.975

• 组织构建循证医学 evidence-based medicine in tissue construction • 上一篇    下一篇

骨质疏松症特异性生命质量量表的系统综述

严  靖1，2，覃湫珺1，李  芬3，周  骏1，丁媛媛1，金春林1   

  1. 1上海市卫生和健康发展研究中心(上海市医学科学技术情报研究所)，上海市  200031；2复旦大学公共卫生学院，上海市  200032；3上海市卫生健康委员会财务管理事务中心，上海市  200040
  • 收稿日期:2024-10-21 接受日期:2024-12-17 出版日期:2025-12-18 发布日期:2025-05-07
  • 通讯作者: 金春林，博士，教授，上海市卫生和健康发展研究中心(上海市医学科学技术情报研究所)，上海市 200031
  • 作者简介:严靖，女，1996年生，在读硕士，主要从事卫生经济学方面的研究。

A systematic review of osteoporosis-specific quality-of-life scales

Yan Jing1, 2, Qin Qiujun1, Li Fen3, Zhou Jun1, Ding Yuanyuan1, Jin Chunlin1   

  1. 1Shanghai Health Development Research Center (Shanghai Medical Information Center), Shanghai 200031, China; 2School of Public Health, Fudan University, Shanghai 200032, China; 3Financial Management Affairs Center of Shanghai Municipal Health Commission, Shanghai 200040, China
  • Received:2024-10-21 Accepted:2024-12-17 Online:2025-12-18 Published:2025-05-07
  • Contact: Jin Chunlin, PhD, Professor, Shanghai Health Development Research Center (Shanghai Medical Information Center), Shanghai 200031, China
  • About author:Yan Jing, Master candidate, Shanghai Health Development Research Center (Shanghai Medical Information Center), Shanghai 200031, China; School of Public Health, Fudan University, Shanghai 200032, China

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摘要：


文题释义：
绝经后骨质疏松症：多见于50岁以上的绝经后妇女，进入绝经期后体内雌激素水平显著下降，从而导致骨量逐渐减少，骨微结构发生退行性变；绝经后骨质疏松症患者发生骨折的风险较高，生活质量较差，有必要进行及时诊断和治疗。
原发性骨质疏松症：与继发性骨质疏松症不同，该病发生于没有其他可识别的骨质流失原因(如药物或疾病等)的情况，主要与雌激素水平下降有关，此外，由于年龄增长而导致的骨强度下降也可引起原发性骨质疏松症的发生。

目的：梳理国内外骨质疏松症特异性生命质量量表的发展趋势、目标人群、设置及构建过程。
方法：通过检索PubMed、Embase、中国知网和万方数据库，识别出目前公开发表的全部骨质疏松症特异性生命质量量表，检索时限为各数据库建库至2024年8月。然后进一步检索纳入量表的原始研发文献，并从中提取量表的基本信息、发展趋势、目标人群，以及维度、条目、水平的设置，并对量表的各维度内容及构建过程进行归纳与分析。
结果：共纳入20个骨质疏松症特异性生命质量量表，并追溯到34篇量表的研发文献。所纳入量表的维度数量在2-7个之间，所有量表均包含生理维度；量表的条目数量在10-84个之间，条目下设的水平数量则多集中于四五个水平。量表的构建主要有3种途径，其中通过构建条目池，并根据经典测量理论和项目反应理论筛选条目是近年来兴起的方式。
结论：根据特定的目标人群和测量目标多样化，骨质疏松症特异性生命质量量表内容愈发精简，无论是维度还是条目数量均呈现减少的趋势，量表的构建过程逐渐趋于规范化。
https://orcid.org/0000-0003-4496-9166(金春林)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 生命质量量表, 骨质疏松症, 特异性, 系统综述, 原发性骨质疏松症, 绝经后骨质疏松症, 生命质量, 量表

Abstract: OBJECTIVE: To review the development trend, target population, setting and construction process of osteoporosis-specific quality of life measures both domestically and internationally. 
METHODS: All of the currently available publicly available osteoporosis-specific quality-of-life scales were found by searching the PubMed, Embase, CNKI, and WanFang Data. The search period included the time from database construction to August 2024. The basic information, development trend, target population, and the setting of the scale’s dimensions, entries, and levels were taken from the original research and development literature that included the scale. The content of the dimensions and the scale’s construction process were then compiled and examined. 
RESULTS: A total of 20 osteoporosis-specific quality of life scales were included in the study, and the literature on the development of 34 scales was traced. The number of dimensions of the included scales ranged from 2-7 dimensions, all of which included physiological dimensions; the number of entries of the scales ranged from 10-84 entries, while the number of levels set under the entries was mostly focused on four or five levels. There are three main ways of constructing the scales, of which the construction of a pool of entries and the screening of the entries according to classical measurement theory and item response theory is an approach that has emerged in recent years.  
CONCLUSION: According to the specific target population and diversified measurement objectives, the content of osteoporosis-specific quality of life scales has become increasingly streamlined, with fewer dimensions and entries overall; and its building procedure is gradually becoming more standardized.

Key words: quality-of-life scale, osteoporosis, specific, systematic review, primary osteoporosis, postmenopausal osteoporosis, quality of life, scale

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