中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (42): 6856-6862.doi: 10.3969/j.issn.2095-4344.2014.42.025

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

神经元钙传感蛋白研究前沿与热点分析

朱玉珍,张庆文   

  1. 上海体育学院体育教育训练学院,上海市  200438
  • 修回日期:2014-09-11 出版日期:2014-10-08 发布日期:2014-10-08
  • 通讯作者: 张庆文,教授,博士生导师,上海体育学院体育教育训练学院,上海市 200438
  • 作者简介:朱玉珍,女,1978年生,上海体育学院在读博士,主要从事运动相关蛋白及体育教育训练学研究。

Research front and hotspots of neuronal calcium sensor-1

Zhu Yu-zhen, Zhang Qing-wen   

  1. College of Physical Education & Training, Shanghai University of Sport, Shanghai 200438, China
  • Revised:2014-09-11 Online:2014-10-08 Published:2014-10-08
  • Contact: Zhang Qing-wen, Professor, Doctoral supervisor, College of Physical Education & Training, Shanghai University of Sport, Shanghai 200438, China
  • About author:Zhu Yu-zhen, Studying for doctorate, College of Physical Education & Training, Shanghai University of Sport, Shanghai 200438, China

摘要:

背景:神经元钙传感蛋白的研究前沿和热点始终是这一领域的研究者共同关注的焦点。
目的:从定量的层面探测神经元钙传感蛋白的前沿领域与研究热点。
方法:以ISI的Web of Science数据库中1982至2014年363篇神经元钙传感蛋白相关文献为分析对象,采用文献共被引分析方法和词频分析方法,运用CiteSpace Ⅲ可视化软件绘制神经元钙传感蛋白文献共被引网络图谱和关键词共现图谱,结合突现节点文献二次检索的方法,梳理并揭示神经元钙传感蛋白的研究前沿与热点。
结果与结论:神经元钙传感蛋白的研究前沿与热点是蛋白质的生理功能,研究热点转变的时间点是1994至1996年,2000年,2008年和2012年。在不同时间阶段,其研究热点也表现出一定的差异性,1992至2000年研究热点是蛋白质的结构和性质,2004至2012年主要集中于研究蛋白质的功能和作用机制。而2008至2014年研究热点是在蛋白质生理功能的研究基础上,更侧重于这一蛋白质的高级功能(如记忆)和各种疾病(如精神分裂症、肿瘤、抑郁症、老年痴呆症、神经元损伤等)的研究。神经元钙传感蛋白前沿领域与研究热点的确定,为今后的研究提供一定的参考。



中国组织工程研究
杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程


全文链接:

关键词: 组织构建, 组织工程, 神经元钙传感蛋白, 研究前沿, 研究热点, 科学知识图谱, CiteSpace, 可视化, 精神病学

Abstract:

BACKGROUND: Research front and hotspots of neuronal calcium sensor-1 are always the focus for the researchers in this field.
OBJECTIVE: To probe the research front and hotspots of neuronal calcium sensor-1 with the methods of quantitative analysis.
METHODS: The methods of co-cited articles analysis and word frequency analysis were used in the article. The objects were 363 articles from Web of Science by US Institute for Scientific Information (ISI) about the neuronal calcium sensor-1 from 1982 to 2014. The network of co-cited articles and keywords was showed in visualization mapping by using CiteSpace III in which the burst nodes represented the high impact hot papers and the most frequently used keywords, and revealed the research frontier and the hot spots of neuronal calcium sensor-1.
RESULTS AND CONCLUSION: The physiological functions of neuronal calcium sensor-1 are the research frontier and the hot spots. The transformational point in time spot of the hotspots is during 1994 to 1996, 2000, 2008, 2012; and the different research focus showed in each stage: the structure and characterization of the protein during 1992-2000 and the protein function and the role during 2004-2012 are the research hotspots, while during 2008-2014 the hotspots place extra emphasis on the higher function (e.g. memory) and several diseases(such as schizophrenia, cancer, autism, depression, senile dementia, neuron damage, etc). The determination of the research frontier domains and hot spots of neuronal calcium sensor-1 will indicate the goal and direction for the further studies.



中国组织工程研究
杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程


全文链接:

Key words: neuronal calcium-sensor proteins, memory, neurons

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