中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (25): 4715-4718.doi: 10.3969/j.issn.1673-8225.2012.25.032

• 生物材料综述 biomaterial review • 上一篇    下一篇

磷硅酸钙类骨水泥的现状与研究进展

郑江江，包崇云   

  1. 四川大学华西口腔医学院口腔疾病研究国家重点实验室，四川省成都市 610041
  • 收稿日期:2011-11-26 修回日期:2011-12-22 出版日期:2012-06-17 发布日期:2013-11-04
  • 通讯作者: 包崇云，博士，教授，四川大学华西口腔医学院口腔疾病研究国家重点实验室，四川省成都市 610041
  • 作者简介:郑江江★，女，1986年生，湖北省孝感市人，汉族，在读硕士，主要从事骨修复替代材料研究。 purphyzjj86@ 163.com
  • 基金资助:

    国家自然科学基金资助(81171005)

Status and research progress of calcium phosphate bone cement

Zheng Jiang-jiang, Bao Chong-yun   

  1. State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2011-11-26 Revised:2011-12-22 Online:2012-06-17 Published:2013-11-04
  • Contact: Bao Chong-yun, Doctor, Professor, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
  • About author:Zheng Jiang-jiang★, Studying for master’s degree, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China purphyzjj86@ 163.com

PDF

486

被引次数

4

摘要：

背景：磷硅酸钙类骨水泥是一种新型的自固化、可注射性骨替代材料。大量实验证实：该材料具有良好的生物活性、生物相容性以及物理化学性质稳定等优点在临床多个领域均有很大进展。
目的：综述磷硅酸钙骨水泥材料的研究现状及进展。
方法：应用计算机检索CNKI、Pubmed数据库中1999-01/2011-10关于新型骨替代材料骨水泥的文章，在标题和摘要中以“磷酸盐类、硅酸盐类、骨水泥、骨替代材料”或“phosphates；silicates；bone cement；bone substitute”为检索词进行检索。选择文章内容与磷硅酸钙类骨水泥有关者，同一领域文献则选择近期发表或发表在权威杂志的文章。初检得到85篇文章，根据纳入标准选择关于磷硅酸钙类骨水泥的13篇文献进行综述。
结果与结论：磷硅酸盐骨水泥作为一种新型的自固化生物材料，较传统骨水泥材料理化性能、生物学性能更为优良，但仍需运用多种方法来研究并改善材料的相关性能。改性后的材料有望发展为各式新型的钙磷硅系骨水泥材料，为骨缺损的修复提供一种新的思路。

关键词: 磷酸盐类, 硅酸盐类, 骨水泥, 骨替代材料, 文献综述, 生物材料

Abstract:

BACKGROUND: Calcium phosphate bone cement is a new kind of self-setting and injectable bone substitute material. Plenty of experiments have proved that there is a great progress in clinical areas of this material due to its good bioactivity, biocompatible and stable physical and chemical properties.
OBJECTIVE: To summarize the status and research progress of calcium phosphate bone cement.
METHODS: A computer-based online search of papers published from January 1999 to October 2011 related to new bone cement was performed in CNKI database, Science direct database and Pubmed database using the key words of “phosphates, silicates, bone cement, bone substitute” by screening titles and abstracts. The documents associated with calcium phosphate bone cement were selected, and those published recently or in authoritative journals were preferred in the same field. Totally 85 articles were obtained in initial retrieval, 13 of them were chosen to summarize based on inclusion criteria.
RESULTS AND CONCLUSION: Calcium phosphate bone cement as a new kind of self-setting bio-material possesses better physical and chemical properties and biological properties compared with traditional bone cement materials. However, the researchers should pay more attention to investigate and improve the properties of this material in order to develop various types of calcium phosphate bone cement and afford novel ideas for repair of bone defects.

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