中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (42): 6330-6336.doi: 10.3969/j.issn.2095-4344.2016.42.015

• 血管组织构建 vascular tissue construction • 上一篇    下一篇

基于有限元分析和集中参数模型微血管与超声微泡声学响应的模拟

牛传筱，郭圣文，邱  霖，劳永华，江行军   

  1. 华南理工大学材料科学与工程学院生物医学工程系，广东省广州市 510006
  • 收稿日期:2016-08-08 出版日期:2016-10-14 发布日期:2016-10-14
  • 通讯作者: 郭圣文，教授，华南理工大学，大学城校区B12国家人体组织功能重建工程技术研究中心502室，广东省广州市 510006
  • 作者简介:牛传筱，女，1990年生，安徽省蚌埠市人，汉族，硕士，主要从事生物力学建模研究。
  • 基金资助:

    国家自然科学基金资助项目(31371008，81171179)；广东省科技计划项目(2015A02024006)

Simulation of acoustic response of microvessel containing microbubble in ultrasound field based on finite element analysis and lumped parameter model

Niu Chuan-xiao, Guo Sheng-wen, Qiu Lin, Lao Yong-hua, Jiang Xing-jun   

  1. School of Material Science and Engineering, South China University of Technology, Guangzhou 510006, Guangdong Province, China
  • Received:2016-08-08 Online:2016-10-14 Published:2016-10-14
  • Contact: Guo Sheng-wen, Professor, School of Material Science and Engineering, South China University of Technology, Guangzhou 510006, Guangdong Province, China
  • About author:Niu Chuan-xiao, Master, School of Material Science and Engineering, South China University of Technology, Guangzhou 510006, Guangdong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31371008, No. 81171179; the Science and Technology Plan of Guangdong Province, No. 2015A02024006

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摘要：

文章快速阅读：

文题释义：
微泡超声对比剂：不仅能增强超声造影，而且也能作为运送基因或药物的载体。在超声作用下, 含基因或药物的微泡能穿透血管内皮，释放基因或药物, 达到靶向治疗目的。 自Gramiak 等将超声微泡对比剂应用于临床以来, 超声微泡的研究得到了很大的发展。特别是第3 代微泡对比剂如Optison®的出现，以白蛋白、非离子表面活性剂、脂质或高分子多聚物为壳膜，内含低弥散度的氟碳气体，使微泡的稳定性显著提高。
微泡振动与外部超声激励、微血管尺寸和管壁弹性间的关系：激励频率增加，微泡的振动幅度减弱，其振动频率增加，而微血管的扩张与收缩幅度减弱，且其能更快地趋于稳定。激励声压变化对微泡与微血管的影响，与激励频率相反；血管的尺寸越小，对微泡振动频率和幅值的限制越强烈，微泡振动频率与振幅均增加，反之亦然；管壁杨氏模量和泊松比增加，微泡的振动幅度降低，但振动频率增加；微泡半径的增加，血管的收缩、扩张幅度和频率均增加。
摘要
背景：研究特定超声激励下微血管与内部单个微泡间的非线性声学响应， 对于最大化超声能量的沉积，促进定量成像算法的发展，揭示损害机制或评价靶向治疗的效果，克服传统方法主要适用于大尺寸血管的局限性、测量微血管弹性意义重大。
目的：构建微血管中超声微泡模型，揭示超声、微泡与血管、血流间的内在机制。
方法：基于有限元分析和集中参数模型，在Comsol Multiphysics 3.5a平台上进行微血管中超声微泡三维模型构建和模拟仿真。
结果与结论：①微泡径向运动因受近处血管壁面限制，移动速度较轴向小；而血管壁因与微泡振动耦合，近微泡的中心处位移和应力最大；②相同声压下，激励频率增加会减弱微血管的缩放且更快趋于稳定；在相同频率下，激励声压越大血管运动越强烈，振动传播产生的局部效应更持久；③微泡振动幅度随微血管壁杨氏模量的增加而降低，近似线性反比关系；振动频率则随血管壁杨氏模量的增加而增加；④结果表明，微血管尺寸越小，对微泡振动频率和幅值的限制越强烈，超声激励频率的增大会使微泡振动频率增大、幅值减小；声压对微泡和血管振动的影响则相反。此外，研究首次发现，血管壁弹性与微泡振动幅度呈近似线性正相关，说明利用微泡测定血管壁弹性是可能的。

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程
ORCID: 0000-0001-6062-1106(郭圣文)

关键词: 组织构建, 组织工程, 生物擦, 微血管, 超声微泡, 非线性声学响应, 血管弹性, 有限元分析, 集中参数模型, 气泡动力学, 国家自然科学基金

Abstract:

BACKGROUND: Exploration on nonlinear acoustic response of the contrast agent microbubble contained in microvessel under ultrasound excitation is of great significance to maximizing ultrasonic energy deposition, promoting the development of quantitative imaging algorithm, revealing the damage mechanism or evaluating the targeted therapy, and overcoming the limitations of the traditional methods that are mainly used in large-size vessels, and measuring microvessel elasticity.
OBJECTIVE: To build a microvessel containing an ultrasound microbubble, revealing the internal mechanism among ultrasound, microbubble, blood flow and microvessel.
METHODS: Based on the finite element analysis and the lumped parameter model, three-dimensional microvessel containing microbubble model was built and simulated on Comsol Multiphysics 4.4 platform.
RESULTS AND CONCLUSION: Microbubble exhibited slower radial motion compared with axial motion due to vascular wall limitation, but maximum displacement and stress were found near the microbubble center because of the oscillation coupling of the microbubble with the vascular wall. Under the same ultrasound pressure, the excitation frequency increased, accompanied by decreased and stabilized microvessl constriction and dilation; under the same frequency, with the enhancement of ultrasound pressure, the local microbubble oscillation lasted longer. With the increase of Young’s modulus of the microvessel wall, the frequency of microbubble oscillation was reduced, while the amplitude increased. All these findings indicate that the frequency of microbubble oscillation increased with the reduction of microvessel size, while its amplitude decreased. The frequency of microbubble oscillation increased with the enhancement of ultrasound excitation, while the amplitude decreased. On the contrary, ultrasound pressure affected the dynamic characteristics of microbubble and microvessel. In particular, it was the first to demonstrate that the elasticity of microvessel has approximate linear positive correlation with the amplitude of microbubble oscillation, which reveals the relationship between microvessel elasticity and microbubble response so as to provide theoretical basis for indirect measurement of microvessel elasticity.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Microvessels, Contrast Media, Tissue Engineering

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