中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (46): 7504-7508.doi: 10.3969/j.issn.2095-4344.2015.46.023

• 组织构建综述 tissue construction review • 上一篇    下一篇

周细胞概念及在血管形成信号转导通路研究中的进展

蒋福林1，艾冬青2，官秋玥3   

  1. 1口腔疾病研究国家重点实验室(四川大学)，四川大学华西口腔医院正畸科，四川省成都市 610041；2口腔疾病与生物医学重庆市重点实验室，重庆医科大学附属口腔医院正畸科，重庆市 401147；3四川省人民医院草堂病区老年病房，四川省成都市 610071
  • 收稿日期:2015-08-19 出版日期:2015-11-12 发布日期:2015-11-12
  • 通讯作者: 官秋玥，主治医师，四川省人民医院草堂病区老年病房，四川省成都市 610071
  • 作者简介:蒋福林，男，1992年生，重庆市人，汉族，四川大学在读硕士，主要从事血管发生与骨代谢的研究。
  • 基金资助:

    国家自然科学基金(81371172)；四川省科技厅应用基础项目(2013JY0031)

Pericyte-related signaling pathways in angiogenesis

Jiang Fu-lin1, Ai Dong-qing2, Guan Qiu-yue3   

  1. 1State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China; 2Chongqing Key Laboratory of Oral Disease and Biomedicine, Department of Orthodontics, the Affiliated Stomatology Hospital of Chongqing Medical University, Chongqing 401147, China; 3Department of Geriatrics, Caotang Branch, Sichuan Provincial People’s Hospital, Chengdu 610071, Sichuan Province, China
  • Received:2015-08-19 Online:2015-11-12 Published:2015-11-12
  • Contact: Guan Qiu-yue, Attending physician, Department of Geriatrics, Caotang Branch, Sichuan Provincial People’s Hospital, Chengdu 610071, Sichuan Province, China
  • About author:Jiang Fu-lin, Studying for master’s degree, State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Supported by:

     the National Natural Science Foundation of China, No. 81371172; the Applied Basic Project of the Science and Technology Department of Sichuan Province, No. 2013JY0031

PDF

289

被引次数

6

摘要：

背景：周细胞广泛分布于除淋巴管外的所有微脉管中，它不仅是微血管的构成成分，还在微血管的发生、发展、稳定、成熟以及再塑形过程中起着重要作用，其信号转导是目前研究的热点。

目的：对近年来周细胞与血管生成相关的信号通路研究进展作以综述。
方法：以“pricytes; endothelial cells；microvessels; signal transduction”为英文关键词；以“周细胞；内皮细胞；微血管；信号转导”为中文关键词，计算机检索PubMed、万方、知网、中国生物医学文献数据库(CBM)，1994至2014年与周细胞、血管生成研究相关的文献，就周细胞及其与内皮细胞相互作用的相关信号通路作一阐述。
结果与结论：毛细血管形成早期，周细胞的募集可促使新生毛细血管的发生和发展；血管形成后期，周细胞则抑制内皮细胞增生，促进内皮细胞分化，从而促进血管成熟，维持正常节构和调节其通透性。血小板衍生生长因子B/血小板衍生生长因子受体β、转化生长因子β、血管生成素1/Tie-2、人肝素结合性表皮生长因子/ ErbBs、基质细胞衍生因子1α/CXCR4等信号通路对周细胞及血管生成发挥着重要的调节作用。
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 组织构建, 组织工程, 周细胞, 内皮细胞, 血小板衍生生长因子, 微血管, 信号转导, 国家自然科学基金

Abstract:

BACKGROUND: Pericytes, which are widely distributed in the microvasculature except lymphatic vessels, are not only a constituent of microvessels, but also play an important role in microvascular occurrence, development, stability, maturity and remodeling. Its signal transduction is currently a hot spot.

OBJECTIVE: To review recent advances in the signal pathways related to pericytes and angiogenesis.
METHODS: We retrieved PubMed database, Wanfang database, CNKI database and China Biology Medicine disc for articles addressing pericytes and angiogenesis published from 1994 to 2014. The keywords were “pricytes; endothelial cells; microvessels; signal transduction” in English and Chinese, respectively.
RESULTS AND CONCLUSION: In the early stage of capillary formation, recruitment of pericytes contributes to the occurrence and development of new blood capillaries. However, in the late stage of angiogenesis, pericytes inhibit endothelial cell proliferation and promote endothelial cell differentiation, thereby promoting vascular maturation, maintaining normal structure and regulating their permeability. In this process, signaling pathways of platelet-derived growth factor B/platelet-derived growth factor receptor β, transforming growth factor β, angiopoietin-1/Tie-2, human heparin binding epidermal growth factor/ErbBs, and stromal cell derived factor 1α/CXCR4 play an important regulatory role in pericytes and angiogenesis.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Platelet-Derived Growth Factors, Receptors, Platelet-Derived Growth Factor, Endothelial Cells, Capillaries