中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (31): 5883-5887.doi: 10.3969/j.issn.1673-8225.2011.31.044

• 肾移植 kidney transplantation • 上一篇    下一篇

肾移植后贫血因素分析：同一机构10年826例移植者资料回顾

曹志强，刘  龙，杨宏伟，范连慧，李昕   

  1. 解放军沈阳军区总医院泌尿外科，辽宁省沈阳市  110016
  • 收稿日期:2011-01-15 修回日期:2011-02-15 出版日期:2011-07-30 发布日期:2011-07-30
  • 通讯作者: 刘龙，硕士，主任医师，解放军沈阳军区总医院泌尿外科，辽宁省沈阳市 110016
  • 作者简介:曹志强★，男，1977年生，黑龙江省双城市人，汉族， 2007年中国医科大学毕业，硕士，主治医师，主要从事泌尿系肿瘤诊治，下尿路疾病诊治研究。

Factors for anemia after kidney transplantation: A data analysis of 826 patients from one institute during 10 years

Cao Zhi-qiang, Liu Long, Yang Hong-wei, Fan Lian-hui, Li Xin   

  1. Department of Urology Surgery, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang   110016, Liaoning Province, China
  • Received:2011-01-15 Revised:2011-02-15 Online:2011-07-30 Published:2011-07-30
  • Contact: Liu Long, Master, Chief physician, Department of Urology Surgery, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, China 15353706127@189.cn
  • About author:Cao Zhi-qiang★, Master, Attending physician, Department of Urology Surgery, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, China cao_zhi_qiang@ yahoo.com.cn

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摘要：

背景: 临床上肾移植后贫血发生率为30%~40%，是肾移植后心血管疾病和移植肾失功的重要危险因素，并且是患者死亡的独立预测指标。
目的：分析肾移植后贫血发生的相关因素。
方法：分析2000-01/2009-12解放军沈阳军区总医院肾移植826例患者资料，其中男541例，女285例，年龄17~71岁；尸体供肾805例，亲体活体供肾21例。根据移植后是否发生贫血将患者分成贫血组与非贫血组，记录可能引起移植后贫血的各项参数，分别用t检验和卡方检验进行单因素分析。
结果与结论：826例肾移植患者中发生贫血225例，发生率为27.2%。女性和男性患者贫血发生率分别为23%和37%(P < 0.05 )；年龄26~65岁，其中伴有高血压应用血管紧张素转化酶抑制剂或血管紧张素Ⅱ受体拮抗剂类降压药物者46例, 伴有慢性糜烂性胃炎或上消化道溃疡者16例，人存活率为85.3%，肾失功率为25.3%；非贫血组601例，占总例数的72.8%，其中男405例，女196例，年龄17~71岁，伴有高血压应用血管紧张素转化酶抑制剂或血管紧张素Ⅱ受体拮抗剂降压药物者35例，伴有慢性糜烂性胃炎或上消化道溃疡者14例，人存活率为92.1%，肾失功率为12.6%，与贫血组对比差异有显著性意义(P < 0.05)。分析表明，性别、年龄、肾功能、消化道疾病史、药物因素等与肾移植后贫血的发生密切相关。

关键词: 肾移植, 贫血, 病因, 治疗, 器官移植

Abstract:

BACKGROUND: Anemia after kidney transplantation has a clinical incidence rate of 30%-40%, is the important risk factor for cardiovascular diseases and kidney failure after kidney transplantation and is also the independent prediction index of patient’s death.
OBJECTIVE: To analyze the factors related to anemia after kidney transplantation.
METHODS: A total of 826 patients, including 541 males and 285 females, aged 18-71 years, who received kidney transplantation in the General Hospital of Shenyang Military Area Command of Chinese PLA from January 2000 to December 2009 were included in this study. Altogether 805 patients received cadaver donor kidney transplantation and 21 patients received living-donor kidney transplantation. All included patients were assigned to two groups: anemia and non-anemia. The possible factors for anemia after kidney transplantation were recorded. t test and chi-square test were used for one-way analysis of variance.
RESULTS AND CONCLUSION: In the anemia group (n = 225, 27.2%, aged 26-65 years), the incidence rate of anemia in female and male patients was 23% and 37%, respectively (P < 0.05), 46 patients had hypertension and used angiotensin-converting enzyme inhibitor or angiotensin Ⅱ receptor antagonist and 16 patients had chronic erosive gastritis or upper gastrointestinal tract ulcer, with the human survival rate of 85.3% and kidney failure rate of 25.3%. In the non-anemia group (n = 601, 72.8%, 405 males, 196 females, aged 18-71 years), 35 patients had hypertension and used angiotensin-converting enzyme inhibitor or angiotensin Ⅱ receptor antagonist and 14 patients had chronic erosive gastritis or upper gastrointestinal tract ulcer, with the human survival rate of 92.1% and kidney failure rate of 12.6%. There was significant difference in above-mentioned indices between anemia and non-anemia groups (P < 0.05). These results suggest that gender, age, kidney function, digestive tract disease history, and drug application are closely related to anemia after kidney transplantation. 

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