中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (26): 4927-4930.doi: 10.3969/j.issn.1673-8225.2011.26.044

• 骨科植入物 orthopedic implant • 上一篇    下一篇

降钙素促进骨质疏松骨床中植入体的骨整合

陈柏龄1，谢登辉1，吕维加2，李佛保1，廖威明1，黎艺强1   

  1. 1中山大学附属第一医院骨科，广东省广州市  510080
    2香港大学医学院创伤与矫形外科系，中国香港
  • 收稿日期:2011-03-05 修回日期:2011-05-10 出版日期:2011-06-25 发布日期:2011-06-25
  • 通讯作者: 陈柏龄☆，男，1968年生，海南省儋州市人，汉族，2001年中山医科大学毕业，博士，副主任医师，主要从事脊柱外科工作。
  • 作者简介:陈柏龄☆，男，1968年生，海南省儋州市人，汉族，2001年中山医科大学毕业，博士，副主任医师，主要从事脊柱外科工作。 并列第一作者：谢登辉。

Calcitonin promotes implant osteointegration in osteoporosis condition

Chen Bai-ling1, Xie Deng-hui1, Lü Wei-jia2, Li Fo-bao1, Liao Wei-ming1, Li Yi-qiang1   

  1. 1Department of Orthopaedics, First Affiliated Hospital of Sun Yat-sen University, Guangzhou  510080, Guangdong Province, China
    2Department of Traumatology and Orthopedics, Medical College, University of Hong Kong, Hong Kong, China
  • Received:2011-03-05 Revised:2011-05-10 Online:2011-06-25 Published:2011-06-25
  • Contact: Chen Bai-ling, Ph. D., Associate chief physician, Department of Orthopaedics, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China berlinch2007@yahoo.com.cn
  • About author:Chen Bai-ling☆, Ph. D., Associate chief physician, Department of Orthopaedics, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China berlinch2007@yahoo.com.cn Xie Deng-hui, Department of Orthopaedics, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China Chen Bai-ling and Xie Deng-hui contributed equally to this article.

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被引次数

2

摘要：

背景：降钙素具有提高骨量、骨质量，降低骨折发生的效果。
目的：评价鲑鱼降钙素对羟基磷灰石植入体骨整合的影响，及其在治疗骨质疏松症同时促进植入体生物学固定的能力。
方法：将SD大鼠随机分为假手术+羟基磷灰石棒组、卵巢切除+羟基磷灰石棒组、卵巢切除+降钙素+羟基磷灰石棒组，后2组建立绝经后骨质疏松动物模型。建模后分别在3组大鼠的胫骨平台处开孔植入多孔羟基磷灰石假体，卵巢切除+降钙素+羟基磷灰石棒组大鼠皮下注射鲑鱼降钙素12周。
结果与结论：卵巢切除后，大鼠的腰椎骨密度降低，而持续皮下注射鲑鱼降钙素后，大鼠的腰椎骨密度逐渐改善。应用降钙素处理后的大鼠，其骨结合率较卵巢切除+羟基磷灰石棒组提高了22.0%(P < 0.05)。结果证实，全身给予鲑鱼降钙素能提高骨质疏松大鼠骨床和植入体周围骨量、促进主体骨-植入体的骨整合。

关键词: 鲑鱼降钙素, 羟基磷灰石, 骨整合, 骨质疏松, 硬组织移入物

Abstract:

BACKGROUND: Calcitonin can increase bone quantity and quality so as to reduce bone fracture occurrence.
OBJECTIVE: To evaluate the effects of calcitonin on implant’s osteointegration and further on promoting the biological fixation of implants in osteoporotic condition.
METHODS: Sprague-Dawley rats were randomly divided into three groups: sham surgery + hydroxyapatite (HA), ovariectomy (OVX) + HA, and OVX + calcitonin + HA groups. Postmenopausal osteoporosis models were established in the OVX + HA and OVX + calcitonin + HA groups. The porous HA prostheses were inserted into the tibial platform in each group after model induction, and rats in the OVX + calcitonin + HA group were given calcitonin for 12 weeks by subcutaneous injection.
RESULTS AND CONCLUSION: Lumbar vertebral bone mineral density (BMD) decreased in OVX + HA group, and the lumbar BMD increased in the OVX + calcitonin + HA group after administration of calcitonin. Comparing with that in OVX + HA group, osseointegration rate in OVX + calcitonin + HA group was increased by 22.0% (P < 0.05). Results verified that in osteoporotic condition, subcutaneous administration of calcitonin could increase bone mass surrounding the implants and promote osteointegration.

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