中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (23): 4336-4339.doi: 10.3969/j.issn.1673-8225.2011.23.036

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞在脑性瘫痪治疗中的应用

王金刚，尹忠民，闻  华   

  1. 解放军第四六三医院神经外科，辽宁省沈阳市  110042
  • 收稿日期:2011-04-06 修回日期:2011-05-09 出版日期:2011-06-04 发布日期:2011-06-04
  • 作者简介:王金刚★，男，1973年生，辽宁省沈阳市人，汉族，硕士，主治医师，主要从事功能神经外科的研究。 windyduan@tom.com

Stem cells for cerebral palsy

Wang Jin-gang, Yin Zhong-min, Wen Hua   

  1. Department of Neurosurgery, the 463 Hospital of Chinese PLA, Shenyang  110042, Liaoning Province, China
  • Received:2011-04-06 Revised:2011-05-09 Online:2011-06-04 Published:2011-06-04
  • About author:Wang Jin-gang★, Master, Attending physician, Department of Neurosurgery, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China windyduan@tom.com

PDF

301

被引次数

5

摘要：

背景：干细胞在适当条件下可以分化为神经元细胞、星形胶质细胞与少突胶质细胞，可能从根本上改善脑性瘫痪患儿神经元缺失及神经胶质细胞变性，进而改善患儿脑功能障碍，从理论上达到根治目的。
目的：回顾性分析不同来源干细胞经不同途径治疗脑性瘫痪患儿的疗效。
方法：由第一作者检索1992/2011 PubMed数据及万方数据库有关脑性瘫痪的治疗及不同来源干细胞在治疗脑性瘫痪等方面的文献。
结果与结论：神经干细胞在动物神经功能损伤中的修复作用已有很多国内外报道，但目前其在人体的临床应用仍处于临床试验阶段。虽然胚胎、骨髓血、胎儿脐带血、脐带来源的干细胞已在部分医院应用到脑性瘫痪患儿中，并取得了初步的疗效，其具体评定标准及长期疗效仍有待进一步随访、观察。

关键词: 脑性瘫痪, 干细胞, 神经干细胞, 间充质干细胞

Abstract:

BACKGROUND: Stem cells under appropriate conditions can differentiate into neurons, astrocytes and oligodendrocytes, which may radically improve neurons loss and glial cell degeneration in cerebral palsy children, thus to improve brain function in children.
OBJECTIVE: To retrospectively analyze the effects of stem cells from different sources on cerebral palsy children.
METHODS: The first author searched PubMed and Wanfang databases (1992/2011) for articles concerning therapies for cerebral palsy and stem cells from different sources for cerebral palsy.
RESULTS AND CONCLUSION: Neural stem cells for animal nerve injury repair have been a reported, but the clinical application of neural stem cells is still in clinical trials. Although embryonic, bone marrow blood, fetal cord blood, umbilical cord-derived stem cells have been applied to child cerebral palsy in some hospitals and a preliminary efficacy has been obtained, the specific evaluation criteria and long-term effects remain to be further studied.

中图分类号: