中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (41): 7719-7722.doi: 10.3969/j.issn.1673-8225.2010.41.029

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

脂肪组织促进创面愈合的机制

何  勇，辛国华，曾逃方   

  1. 南昌大学第一附属医院烧伤中心，江西省南昌市 330006
  • 出版日期:2010-10-08 发布日期:2010-10-08
  • 通讯作者: 辛国华，副教授，主任医师，南昌大学第一附属医院烧伤中心，江西省南昌市 330006 xinguoh@126.com
  • 作者简介:何勇★，男，1981年生，江西省新干县人，汉族，南昌大学在读硕士，主要从事烧伤创面处理及愈合的研究。 heyong_8123@yahoo.cn
  • 基金资助:

    课题受江西省卫生厅项目(20093028)资助。

Mechanisms of wound healing accelerated by adipose tissue

He Yong, Xin Guo-hua, Zeng Tao-fang   

  1. Burn Center, First Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China
  • Online:2010-10-08 Published:2010-10-08
  • Contact: Xin Guo-hua, Associate professor, Chief physician, Burn Center, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China xinguoh@126.com
  • About author:He Yong★, Studying for master’s degree, Burn Center, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China heyong_8123@yahoo.cn
  • Supported by:

     the Health Department of Jiangxi Province, No. 20093028*

PDF

417

被引次数

37

摘要：

背景：随着对脂肪组织研究的不断深入，脂肪组织在创面愈合中的作用备受关注，脂肪组织促进创面愈合的机制以及应用方面的研究广泛开展。
目的：文章从脂肪因子和脂肪干细胞两方面探讨脂肪组织促进创面愈合的机制，并就相关应用研究进行归纳分析，为临床创面治疗提供理论依据。
方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：2009/2010）和PubMed数据库(2009/2010)，检索词分别为“脂肪组织，瘦素，抵抗素，脂肪干细胞，创面愈合”和“adipose tissue，leptin，resistin，adipose-derived stem cells，wound healing”，语言分别设定为中文和英文。从脂肪因子和脂肪干细胞两方面入手，对脂肪组织促进创面愈合的机制及脂肪组织促进创面愈合的现有研究进行介绍。
结果与结论：共检索到文献329篇，阅读标题和摘要后，按纳入标准，共纳入31篇。总结并分析文献内容后发现，血管再生、成纤维细胞及角朊细胞等的增殖是创面愈合的关键，而脂肪组织可通过脂肪干细胞及分泌脂肪因子促进血管内皮、成纤维、角朊等细胞增殖的方式，促进创面愈合，提高创面愈合质量。但有关创烧伤过程脂肪因子的调控机制，脂肪干细胞增殖、分化的机制，以及如何进而进一步提高创面愈合速率及质量等问题，仍需进一步研究。

关键词: 脂肪组织, 创面愈合, 瘦素, 抵抗素, 生长因子, 脂肪干细胞

Abstract:

BACKGROUND: With the research developments of adipose tissue, the effect of adipose tissue on wound healing has aroused increasing attention. The mechanisms of wound healing accelerated by adipose tissue and its application have been widely carried out. 
OBJECTIVE: To provide the theoretical basis for clinical wound treatment via investigating the mechanisms of adipose tissue on accelerate wound healing from aspects of adipokines/adipocytokines and adipose-derived stem cells and reviewing their applications.
METHODS: CNKI and PubMed databases were searched by the first author using key words of “adipose tissue, leptin, resistin, adipose-derived stem cells, wound healing” from 2009 to 2010. The language was limited for Chinese and English. The mechanisms of adipose tissue on accelerate wound healing and their applications were introduced from adipokines/adipocytokines and adipose-derived stem cells.
RESULTS AND CONCLUSION: A total of 329 papers were searched, and 31 documents were included according to inclusive criteria. The results showed that, the proliferation of vascular regeneration, fibroblast and keratinocytes play a key role in wound healing, adipose tissue can promote and improve the quality of wound healing through the proliferation of vascular endothelial, fibroblasts, keratinocytes and other cells. However, the regulation of adipokines/adipocytokines during wound healing, the mechanism of adipose-derived stem cells proliferation and differentiation, as well as how to improve the healing rate, remain poorly understood.

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