中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (38): 7112-7115.doi: 10.3969/j.issn.1673-8225.2010.38.020

• 生物材料基础实验 basic experiments of biomaterials • 上一篇    下一篇

左旋多巴改性有机-无机复合药物洗脱支架涂层的制备

陈文平1，詹红兵2，李昭辉3，冯  苗2，刘  维2，肖  勇2   

  1. 福州大学，1材料学院， 2材料科学与工程学院，福建省福州市 350108；3厦门大学附属中山医院血管外科，福建省厦门市   361004
  • 出版日期:2010-09-17 发布日期:2010-09-17
  • 通讯作者: 詹红兵，博士，教授，博士生导师，福州大学材料科学与工程学院，福建省福州市 350108 hbzhan@fzu.edu.cn
  • 作者简介:陈文平★，女，1985年生，福建省永泰县人，汉族，福州大学在读硕士，主要从事有机-无机复合心血管支架药物控释涂层材料研究。 wpchen1985@163.com

Preparation of 3,4-Dihydroxy-L-phenylalanine modified organic-inorganic hybrid coatings for drug eluting stents

Chen Wen-ping1, Zhan Hong-bing2, Li Zhao-hui3, Feng Miao2, Liu Wei2, Xiao Yong2   

  1. 1 College of Materials Science, 2 College of Material Science and Engineering, Fuzhou University, Fuzhou   350108, Fujian Province, China; 3 Department of Vascular Surgery, Zhongshan Hospital, Xiamen University, Xiamen   361004, Fujian Province, China
  • Online:2010-09-17 Published:2010-09-17
  • Contact: Zhan Hong-bing, Doctor, Professor, Doctoral supervisor, College of Material Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China hbzhan@fzu.edu.cn
  • About author:Chen Wen-ping★, Studying for master’s degree, College of Materials Science, Fuzhou University, Fuzhou 350108, Fujian Province, China wpchen1985@163.com

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369

被引次数

1

摘要：

背景：目前，药物主要是通过支架表面的涂层实现其装载和释放，且使用的药物装载涂层材料多为高分子材料。但临床研究发现，高分子材料使用带来的后期血栓问题以及植入后基体表面涂层完整性不被破坏成为新的挑战。
目的：制备一种新型的有机-无机复合涂层作为支架药物载体，在降低高分子的使用并实现药物缓释同时保持涂层弹性及涂层与基体间良好的粘结性。
方法：采用溶胶凝胶法在316L不锈钢表面制备左旋多巴改性的二氧化硅-聚乙二醇涂层。以阿司匹林为示范药物，研究药物装载方式对释放动力学的影响。通过金相显微镜观察涂层表面形貌，用紫外可见光谱测其释放动力学。
结果与结论：左旋多巴改性二氧化硅-聚乙二醇涂层与基体结合良好，克服了原涂层容易开裂、剥落的现象。溶胶凝胶过程中引入阿司匹林能够实现药物在40 h内缓慢线性释放，而通过浸泡扩散实现药物装载的涂层，1 h内释放出总装载量的75%，出现了药物爆释现象。实验成功制备了一种新型的药物可控释性有机-无机复合涂层材料，左旋多巴A的黏结性和自交联性可以很好地解决涂层与基体黏结性差、涂层容易开裂弹性差等问题。在溶胶凝胶过程中同时装载的阿司匹林能够实现在基质中的线性释放，避免了爆释现象。

关键词: 左旋多巴, 溶胶凝胶法, 阿司匹林装载, 药物洗脱支架涂层, 药物控释系统及其载体材料

Abstract:

BACKGROUND: It’s the stent coatings, most of which are polymers, that play the role of drug carrying and realize the controlled release of the loaded drugs. But clinical trial demonstrates that the late stent thrombosis associated with polymers and the difficulties in drug release control and integrity maintenance are the main challenges currently.
OBJECTIVE: To prepare a novel organic-inorganic hybrid coating with controllable drug release, strong adhesion and excellent flexibility while lowering the use of polymer.
METHODS: 3,4-Dihydroxy-L-phenylalanine (L-DOPA) modified SiO2-PEG hybrid was prepared by sol-gel technique and dip coated onto 316L stainless steel substrate. Aspirin was chosen as sample drug to elucidate the influence of loading method on the releasing dynamics. The surface morphology was investigated by metalloscope and the aspirin release profile was tested by UV/Vis absorption spectra.
RESULTS AND CONCLUSION: The addition of L-DOPA greatly improved the adhesion of SiO2-PEG coating to the substrate. Cracks and warps were effectively avoided. Compared with the burst release, 75% total loading within 1 hour, of aspirin which was loaded by dipping and diffusion, the introducing of aspirin during the sol-gel process can realize a linear and sustained release within 40 hours. A new experimental organic-inorganic coating material with drug controlled-release can successfully fabricated, L-DOPA bonding and self-crosslinking properties are sufficient to solive poor bonding between coating and substrate, easy cracking and poor flexibility of the coating. Aspirin loaded in the sol-gel process can achieve a linear release in the substrate, avoiding burst release phenomenon.

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