中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (35): 6525-6528.doi: 10.3969/j.issn.1673-8225.2010.35.016

• 骨与关节图像与影像 bone and joint imaging • 上一篇    下一篇

不同条件髋部骨骼的短期精密度差异：双能X射线骨密度仪测量

康后生1，赵  雨1，代小思2，任玲俐1，邱  平1，刘  琳1，彭乙华1，孙  昆1   

  1. 1川北医学院附属医院内分泌科，四川省南充市 637000；2川北医学院人体解剖教研室，四川省南充市  637000
  • 出版日期:2010-08-27 发布日期:2010-08-27
  • 作者简介:康后生，男，1965年生，四川省合江县人，汉族，1990年泸州医学院毕业，副教授，主要从事骨质疏松及糖尿病方面的研究。 khs326@163.com
  • 基金资助:

    四川省卫生厅科研课题，编号090154，课题名称“双能X射线吸收法(DXA)髋部骨密度测量质量控制中的精密度研究”。

Short-term precision differences in hip skeleton at different conditions: Determination by using dual-energy X-ray absorptionmetry

Kang Hou-sheng1, Zhao Yu1, Dai Xiao-si2, Ren Ling-li1, Qiu Ping1, Liu Lin1, Peng Yi-hua1, Sun Kun1   

  1. 1 Department of Endocrinology, Affiliated Hospital of North Sichuan Medical College, Nanchong  637000, Sichuan Province, China; 2 Teaching and Research Section of Anatomy, North Sichuan Medical College, Nanchong  637000, Sichuan Province, China
  • Online:2010-08-27 Published:2010-08-27
  • About author:Kang Hou-sheng, Associate professor, Department of Endocrinology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China khs326@163.com
  • Supported by:

    the Scientific Research Program of Sichuan Provincial Health Department, No. 090154*

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摘要：

背景：对骨密度测量的方法有多种多样，但对髋部不同程度骨质疏松测定方面的质量控制国内目前尚未见报道。
目的：比较应用DPX-MD双能X射线骨密度仪测量髋部不同程度骨质疏松骨的短期精密度差异。
方法：根据骨质疏松程度分类标准，将20例受试者分为骨量正常组、骨量减少组、骨质疏松组、严重骨质疏松组。1个附带软组织的死体髋部由川北医学院人体解剖实验室提供。采用DPX-MD双能X射线骨密度仪测量每例受试者髋部骨骼的骨密度，1次/d，连续测定5 d。各部位的骨密度值以均值±标准差表示，由不同骨密度的均值除标准差得到变异系数，即短期精密度。
结果与结论：髋部的股骨颈、Ward三角区、大转子、大转子内区、髋部总体这5个区域比较，各组每例受试者均为髋部总体骨密度的变异系数最小，说明髋部总体区的短期精密度最好，股骨颈次之，Ward三角区骨密度的变异系数最大，这可能与其难准确定位有关。骨量正常组骨密度变异系数小于骨量减少组、骨质疏松组、严重骨质疏松组，其短期精密度最好，死体各区域骨密度的变异系数值均大于上述4组，说明其短期精密度最差。结果提示不同条件髋部骨骼的短期精密度存在差异，在临床药物疗效观察过程中进行骨密度检测时，可选择影响最小的髋部总体区域，其次为股骨颈部位。

关键词: 双能X射线骨密度仪, 髋部, 变异系数, 骨质疏松, 骨密度, 短期精密度

Abstract:

BACKGROUND: There are many methods for measuring bone density, but no study reports quality control of measurements in different degrees of osteoporosis.
OBJECTIVE: To compare short-tem precision of DPX-MD dual-energy X-ray absorptionmetry in measuring hip of different degree osteoporosis.
METHODS: According to osteoporosis degree, 20 patients were divided into normal, decreased bone mass, osteoporosis, and severe osteoporosis groups. One hip with soft tissues from corpse was provided by Laboratory of Anatomy, North Sichuan Medical College. Hip bone density of each subject was measured using DPX-MD dual-energy X-ray absorptionmetry, once a day for 5 days. The bone density was expressed as Mean±SD, and coefficient of variation was obtained by mean of different bone densities dividing standard deviation.
RESULTS AND CONCLUSION: Among femoral neck, Ward’s triangle, greater trochanter, inner zone of greater trochanter, and entire hip, the coefficient of variation of the entire hip was the smallest in all subjects, suggesting the best short-term precision of the entire hip, followed by femoral neck. The coefficient of variation of Ward’s triangle was the largest. The coefficient of variation of normal group was less than decreased bone mass, osteoporosis, and severe osteoporosis groups, but normal group exhibited the best short-term precision. The coefficient of variation of corpse at each region was greater than the four groups, suggesting the worst short-term precision. Results show that there are differences in short-term precision among hip skeleton. Therefore, the entire hip region and femoral neck with little influence can be used for bone density detection during observation of clinical drug effects.

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