中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (28): 5281-5284.doi: 10.3969/j.issn.1673-8225.2010.28.036

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

卫星细胞与肌肉肥大关系及成肌因子的运动性调控

王今越1，王小虹2，陈民盛3，杨海东4   

  1. 1佛山大学体育学院，广东省佛山市 528000；2东北师范大学体育学院，吉林省长春市 130026；3深圳大学体育部，广东省深圳市  518060；4东北大学体育部，辽宁省沈阳市 110004
  • 出版日期:2010-07-09 发布日期:2010-07-09
  • 作者简介:王今越☆，男，1978年生，吉林省长春市人，满族，博士，讲师，2008年华东师范大学体育健康学院毕业，主要从事运动适应与机能评定方面的研究。 wjytnt@tom.com
  • 基金资助:

    本课题受吉林省科技引导计划（2010D715）和吉林省体育局课题基金(07B04、09B12、09B15)资助。

Correlation between satellite cells and muscle hypertrophy as well as exercise regulation of myogenic factor 

Wang Jin-yue1, Wang Xiao-hong2, Chen Min-sheng3, Yang Hai-dong4   

  1. 1 Physical Education College, Foshan University, Foshan 528000, Guangdong Province, China; 2 Physical Education College, Northeast Normal University, Changchun  130026, Jilin Province, China; 3 Physical Education College, Shenzhen University, Shenzhen 518060, Guangdong Province, China; 4 Physical Education College, Northeast University, Shenyang 110004, Liaoning Province, China
  • Online:2010-07-09 Published:2010-07-09
  • About author:Wang Jin-yue☆, Doctor, Lecturer, Physical Education College, Foshan University, Foshan 528000, Guangdong Province, China wjytnt@tom.com
  • Supported by:

    the Science and Technology Guidance plan of Jilin Province, No.2010D715*; Subjects of Physical Education Bureau of Jilin Province, No.07B04*, 09B12*, 09B15*

PDF

577

被引次数

2

摘要：

背景：卫星细胞是成体肌肉发生重要的“原料”，它的增殖、分化和融合增加了肌纤维的细胞核数量或肌纤维数的数量，继而引起肌肉功能和形态学的变化，但是肌肉肥大是否一定有卫星细胞参与还存在争议。成肌因子是肌肉发生调节的核心因子，在肌肉发生的多个阶段发挥重要作用，但是目前对它们功能上特点和差异的了解仍然不够深入。
目的：总结并讨论卫星细胞和成肌因子在肌肉发生和肌肉肥大以及在肌肉训练中的作用。
方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：2000/2010)和Medline(2000/2010)数据库，检索词分别为“骨骼肌，肥大，运动，肌肉发生，卫星细胞，成肌因子”和“skeletal muscle，hypertrophy，exercise，myogenesis，satellite cell，MRF”，语言分别设定为中文和英文。从卫星细胞与肌肉肥大、成肌因子的作用及成肌因子的运动性调控特点2方面进行总结，对卫星细胞及成肌因子在肌肉发生中的作用及其调节机制和肌肉重塑等方面进行介绍。
结果与结论：共检索到177篇文章，按纳入和排除标准对文献进行筛选，共纳入30篇文章。结果表明肌肉发生是肌肉肥大的生物学基础，卫星细胞是成体肌肉发生关键，但肌肉肥大早期过程可能没有卫星细胞的参与，以DNA含量来衡量卫星细胞改变可能有较大误差，成肌因子是肌肉发生核心因子。目前研究对成肌因子成员之间功能的异同和成肌因子的运动性调控特点的了解仍不深入。

关键词: 成肌因子, 骨骼肌, 肥大, 运动, 肌肉发生, 卫星细胞

Abstract:

BACKGROUND: Satellite cells, which proliferate, differentiate and fuse to increase the quantities of nucleuses and myofibers, and then change the function or morphology of skeletal muscle, are the material of myogenesis. Whether muscle hypertrophy might be independent on satellite cells or not is still controversial. Myogenic factors (MRFs) are key factors of myogenesis. However, characteristics and difference among them remain unclear.
OBJECTIVE: To summarize and investigate the effect of satellite cells or MRFs on myogenesis, muscle hypertrophy and musde training.
METHODS: A computer-based online search was conducted in CNKI and Medline databases with the key words of “skeletal muscle, hypertrophy, exercise, myogenesis, satellite cell, MRF” in both Chinese and English from 2000 to 2010. The relation between satellite cells and muscle hypertrophy, funtion and exercise-regulation of MRFs was summarized; while, regulatory mechanism and muscle remolding were investigated.
RESULTS AND CONCLUSION: A total of 177 articles were retrieved. According to inclusion and exclusion criteria, 30 articles were included in the final analysis. The results demonstrated that myogenesis was a basis of muscle hypertrophy, and satellite cells played a key role in myogenesis. However, satellite cells did not participate in early phase of muscle hypertrophy, thus DNA was not a good index to determine changes of satellite cells. MRFs were core factors to cause myogenesis. At present, function and motor regulation of MRFs still need to be further studied.

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