中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (28): 5260-5263.doi: 10.3969/j.issn.1673-8225.2010.28.031

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

软骨组织工程中相关生长因子理论研究的最新资讯

李  成1，王  伟1，2   

  1. 1辽宁医学院，辽宁省锦州市  121000；2锦州市中心医院骨科，辽宁省锦州市 121000
  • 出版日期:2010-07-09 发布日期:2010-07-09
  • 通讯作者: 王伟，教授，博士生导师，辽宁医学院，辽宁省锦州市 121000；锦州市中心医院骨科，辽宁省锦州市 121000 Weiwang_ly@yahoo.com.cn
  • 作者简介:李 成★，男，1978年生，辽宁省锦州市人，辽宁医学院在读硕士，主治医师，主要从事关节软骨修复方面的研究。 Licheng19780101@163.com

Latest information addressing related growth factors in cartilage tissue engineering 

Li Cheng1, Wang Wei 1,2   

  1. 1 Liaoning Medical University, Jinzhou  121000, Liaoning Province, China; 2 Department of Orthopaedics, Jinzhou Central Hospital, Jinzhou  121000, Liaoning Province, China
  • Online:2010-07-09 Published:2010-07-09
  • Contact: Wang Wei, Professor, Doctoral supervisor, Liaoning Medical University, Jinzhou 121000, Liaoning Province, China; Department of Orthopaedics, Jinzhou Central Hospital, Jinzhou 121000, Liaoning Province, China Weiwang_ly@yahoo.com.cn
  • About author:Li Cheng★, Studying for master’s degree, Attending physician, Liaoning Medical University, Jinzhou 121000, Liaoning Province, China Licheng19780101@163.com

PDF

363

被引次数

11

摘要：

背景：目前尚无理想的方法促进软骨的修复与再生。
目的：就近年来软骨组织工程中相关细胞因子的研究进展做一综述。
方法：以“软骨，细胞因子，组织工程”为中文检索词；以“cartilage，cell factor，Tissue Engineering”为英文检索词，检索Pubmed数据库和CHKD期刊全文数据库1997-01/2009-01与软骨组织工程中相关生长因子相关的文献，排除重复性研究，保留38篇文献做进一步分析。
结果与结论：研究表明转化生长因子β、成纤维生长因子、胰岛素样生长因子、骨形态发生蛋白，以及近年发现的软骨源性形态发生蛋白等细胞因子对软骨修复有着非常重要的影响，这些因子介导了软骨修复的整个过程，能促进软骨细胞增殖分化和诱导细胞发挥功能。目前对细胞因子的研究多处于实验阶段，其在体内应用时可对其他组织产生分化、代谢和致突变作用，细胞因子临床应用的安全性还有待提高。

关键词: 软骨, 细胞因子, 软骨组织工程, 转化生长因子&beta, 成纤维生长因子, 胰岛素样生长因子, 骨形态发生蛋白

Abstract:

BACKGROUND: There is not an ideal way to promote cartilage repair and regeneration.
OBJECTIVE: To review the research progress of related growth factor in cartilage tissue engineering.
METHODS: PubMed and CHKD databases were retrieved with key words of “cartilage, cell factor, tissue engineering” both in Chinese and English to search articles published between January 1997 and January 2009. Totally 38 papers were included for further analysis after removing repetitive studies.
RESULTS AND CONCLUSION: Studies demonstrated that cytokine, such as transforming growth factor β, fibroblast growth factor, insulin-like growth factors, bone morphogenetic protein, as well as cartilage-derived morphogenetic protein and other cell factors have significant impacts on cartilage repair. These factors mediate the entire process of cartilage repair, which can promote the proliferation and differentiation of cartilage cells and guide these cells to play its function. Presently, most studies concerning cytokine are at experimental levels, the safety of which in clinic still should be improved.

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