中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (28): 5264-5267.doi: 10.3969/j.issn.1673-8225.2010.28.032

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

骨粘连蛋白的理论研究与临床应用

汤译博，赵  亮，苏佳灿   

  1. 解放军第二军医大学附属长海医院骨科，上海市 200433
  • 出版日期:2010-07-09 发布日期:2010-07-09
  • 通讯作者: 苏佳灿，博士，博士后，副主任医师，副教授，解放军第二军医大学附属长海医院骨科，上海市 200433 sujiacan@yahoo.com.cn
  • 作者简介:汤译博☆，男，江苏省宜兴市人，汉族，解放军第二军医大学在读博士，医师，主要从事创伤骨科方面研究。 tybmoro@yahoo.com.cn
  • 基金资助:

    上海市科委纳米专项基金(0852nm04300)；上海市人事局人才发展资金；上海市卫生局专项基金(2009S018)；上海市高校优秀青年教师专项基金

Theoretical study and clinical application of osteonectin

Tang Yi-bo, Zhao Liang, Su Jia-can    

  1. Department of Orthopaedics, Changhai Hospital, the Second Military Medical University, Shanghai  200433, China
  • Online:2010-07-09 Published:2010-07-09
  • Contact: Su Jia-can, Doctor, Associate chief physician, Associate professor, Department of Orthopaedics, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China sujiacan@yahoo.com.cn
  • About author:Tang Yi-bo☆, Studying for doctorate, Physician, Department of Orthopaedics, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China tybmoro@yahoo.com.cn
  • Supported by:

    the Nanometer Special Foundation of Science Committee of Shanghai, No. 0852nm04300*; Special Foundation for Talent Development of Personnel Bureau of Shanghai*; Special Foundation of Health Bureau of Shanghai, No. 2009S018*; Foundation for the Excellent Youth Scholars of Shanghai*

PDF

455

被引次数

9

摘要：

背景：近年来研究发现，骨粘连蛋白作为广泛分布的一种细胞外基质蛋白，与骨的生长和重建、肿瘤发生、细胞分化等多种生命活动有关。
目的：对骨粘连蛋白的结构、主要生物学功能进行简要综述，从而较全面地概括其各方面可能存在的作用。
方法：由第一作者检索2000/2010 PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及万方数据库(http://www. wanfangdata.com.cn)。英文检索词为“osteonectin, SPARC, matricellular protein, fracture healing, tumorigenesis”，中文检索词为“骨粘连蛋白，细胞外基质蛋白，骨折愈合，肿瘤发生”。计算机初检得到59篇文献，根据纳入标准保留27篇进一步归纳总结。
结果与结论：作为一种广泛表达的细胞外蛋白，骨粘连蛋白不仅能作为细胞外基质的结构蛋白，同时也能作为多种物质的调节蛋白。骨粘连蛋白主要通过与Ca2+及胶原结合的方式，调节多种生命活动，但对其的研究仍处于初步阶段，其具体分子机制尚不清楚。另一方面，虽然有许多骨粘连蛋白病理状态下在人体内异常表达的报道，但有关骨粘连蛋白的前瞻性研究至今仍停留在动物实验及体外细胞实验，主要是用骨粘连蛋白基因敲除的小鼠进行研究，而将其应用于临床或许还有较为长远的过程。但是可以预见，随着对其研究的不断深入，骨粘连蛋白会在骨折愈合、肿瘤治疗等临床领域取得新的突破。

关键词: 骨粘连蛋白, 骨折愈合, 肿瘤发生, 生物材料, 综述文献

Abstract:

BACKGROUND: Osteonectin is a unique matricellular glycoprotein that is expressed by many different types of cells. As an important component of matricellular matrix, osteonectin contributes to developing and remodeling of bone, tumorigenesis, cell turnover and differentiation.
OBJECTIVE: To review and summarize the structure and functions of osteonectin, and to assess the role of osteonectin comprehensively.
METHODS: The relevant articles between 2000 and 2010 were retried from PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang (http://www.wanfangdata.com.cn) using the key words of “osteonectin, SPARC, matricellular protein, fracture healing, tumorigenesis” by the first author. A total 59 literatures were retrieved, and 27 met the inclusion criteria were further analyzed.
CONCLUSION: As a widely expressed matricellular protein, osteonctin not only served as structural protein of extracellular matrix, but also served as regulatory protein for many materials. Osteonctin plays an important role in many biological functions via binding to Ca2+ and collagen, but the study is still at the preliminary step and the mechanism remains unclear. On the other hand, it is reported that osteonctin was abnormal expressed in pathologic state, but the perspective study still limited in animal experiment and in vitro cell experiment, thus, it is far from clinical application. However, osteonctin has breakthrough in treating bone union and tumor with the deepening of studies. 

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