中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (22): 4115-4118.doi: 10.3969/j.issn.1673-8225.2010.22.032

• 骨与关节学术探讨 academic discussion of the bone and joint • 上一篇    下一篇

支架置入与冠状动脉粥样硬化性心脏病患者QT离散度及校正QT离散度变化

刘晓方1，张福利2   

  1. 1沈阳医学院附属沈洲医院电诊科研室，辽宁省沈阳市  110002；2中国医科大学生物物理教研室，辽宁省沈阳市 110001
  • 出版日期:2010-05-28 发布日期:2010-05-28
  • 作者简介:刘晓方，男，1954年生，山东省淄博市人，汉族，1984年中国医科大学毕业，主治医师，主要从事冠心病心电图方向研究。 ts_3193@163.com

Stent implantation and changes in QT dispersion and corrected QT dispersion in patients with coronary atherosclerotic heart disease

 Liu Xiao-fang1, Zhang Fu-li2   

  1. 1 Department of Electrodiagnosis, Shenzhou Hospital, Shenyang Medical College, Shenyang   110002, Liaoning Province, China; 2 Deparmtent of Biophysics, China Medical University, Shenyang   110001, Liaoning Province, China
  • Online:2010-05-28 Published:2010-05-28
  • About author:Liu Xiao-fang, Attending physician, Department of Electrodiagnosis, Shenzhou Hospital, Shenyang Medical College, Shenyang 110002, Liaoning Province, China ts_3193@163.com

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375

被引次数

9

摘要：

目的：探讨支架置入临床应用特点及其对冠状动脉粥样硬化性心脏病患者QT离散度及校正QT离散度的影响。
方法：应用万方数据库和中国期刊全文数据库(CNKI)，由第一作者以“支架置入，QT离散度，校正QT离散度”等检索1998/2010时限内与支架置入对冠状动脉粥样硬化性心脏病患者QT离散度影响有关的文献。排除重复研究或较陈旧文献。
结果：依据纳入排除标准共保留文献22篇。常用支架为金属裸支架与药物支架。金属裸支架置入操作简便易行，并具有形状记忆效应及良好的生物相容性等临床应用优势，但术后早期再狭窄发生率高；药物支架有效降低术后再狭窄发生率，但远期安全性尚不明确。同时因经济投入高、置放技术要求严格等不易进行临床推广。从临床应用效果来看，支架置入显著缩短冠心病患者QT离散度以及校正QT离散。
结论：支架置入显著缩短QT离散度以及校正QT离散，有效改善心肌再灌注，降低恶性心血管事件发生率，改善患者长期预后。但不同类型支架置入引起QT离散度的对应性变化，尚需进一步研究。

关键词: 支架置入, 冠状动脉粥样硬化性心脏病, QT离散度, 校正QT离散度

Abstract:

OBJECTIVE: To explore the clinical application features of stent implantation and its effect on QT dispersion (QTd) and QTd correction in patients with coronary atherosclerotic heart disease.
METHODS: A computer-based online search of Wanfang and CNKI databases was performed for articles regarding effect of stent on QTd in patients with coronary atherosclerotic heart disease. Repetitive articles or outdate studies were excluded.
RESULTS: A total of 22 articles were included. Common stents include metal bare and drug stents. Metal bare stent implantation is simple with memory effect and good biocompatibility. However, early restenosis incidence is high. Drug stent effectively reduces restenosis incidence, but the long-term safety remains unclear. In addition, the high cost and skiu limit its application. Stent implantation significantly shortens QTd and corrected QTd clinically.
CONCLUSION: Stent implantation significantly shortens QTd and corrected QTd, effectively improves myocardial reperfusion, reduces malignant cardiovascular events incidence, and improves long-term prognosis. However, further researches are still needed to check whether different types of stent implantation induce corresponding changes in QTd.

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