中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (12): 2273-2276.doi: 10.3969/j.issn.1673-8225.2010.12.046

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

电纺丝聚乳酸、聚3羟基丁酸酯共聚4羟基丁酸酯和聚碳酸亚丙酯纳米纤维的制备及表面亲水性

李  楠1，王雪明1，齐宏旭2，翟俊山1，王  艳2，胡  平2，朱建华1   

  1. 1解放军总参谋部总医院(解放军第309医院)消化科，北京市　100091；2清华大学化工系高分子材料研究室，北京市　100084
  • 出版日期:2010-03-19 发布日期:2010-03-19
  • 作者简介:李 楠☆，男，1957年生，山东省青岛市人，汉族，1996年解放军第三军医大学毕业，博士，教授，主任医师，博士生导师，主要从事消化内镜新技术研究及临床应用。
  • 基金资助:

    国家食品卫生质量监督检验中心“十一五重点攻关课题”(09SJ0019) 。课题名称：纳米材料消化道可降解支架的制备及安全性评估。

Electrospinning preparation and surface hydrophilicity investigation of poly(lactic acid), poly(3-hydroxybutyrate- o-4-hydroxybutyrate), and poly(propylene carbonate) nanometer fiber membranes

Li Nan1, Wang Xue-ming1, Qi Hong-xu2, Zhai Jun-shan1, Wang Yan2, Hu Ping2, Zhu Jian-hua1   

  1. 1 Department of Gastroenterology, PLA General Staff Headquarter General Hospital (309th Hospital of Chinese PLA), Beijing   100091, China; 2 Institute of Polymer Science and Technology, Department of Chemical Engineering, Tsinghua University, Beijing   100084, China
  • Online:2010-03-19 Published:2010-03-19
  • About author:Li Nan☆, Doctor, Professor, Chief physician, Doctoral Supervisor, Department of Gastroenterology, PLA General Staff Headquarter General Hospital (309th Hospital of Chinese PLA), Beijing 100091, China linan957@sina.com
  • Supported by:

    High-Tech Research and Development Program of National Food Quality Supervision and Inspection Center during the Eleventh Five-Year Plan Period, No. 09SJ0019*

PDF

444

被引次数

15

摘要：

背景：近年来聚乳酸、羟基磷灰石类复合材料支架具有良好的生物降解性和生物相容性而被广泛的研究，但是这类复合材料在增强材料界面的结合、调节材料的降解速率、改善材料的强度等方面仍不能满足理想的组织工程支架材料的要求。
目的：探讨电纺丝法制备纳米纤维的结构形态及表面亲水性。
方法：分别将聚乳酸、聚3羟基丁酸酯共聚4羟基丁酸酯和聚碳酸亚丙酯通过静电纺丝法制备纳米纤维膜，扫描电镜对纤维膜的结构形态进行分析，并观察在人体环境相近的磷酸盐缓冲溶液(37 ℃，pH 7.4)中浸泡不同时间的表面亲水性。
结果与结论：通过静电纺丝技术可以将聚乳酸、聚3羟基丁酸酯共聚4羟基丁酸酯和聚碳酸亚丙酯3种材料制备成微纳米纤维结构，控制制备参数可以获得不同直径的纤维，样品随着在培养液中的浸泡时间延长，总体显示出接触角比初始降低，亲水性增强。

关键词: 聚乳酸, 聚3羟基丁酸酯共聚4羟基丁酸酯, 聚碳酸酯, 电纺丝, 亲水性

Abstract:

BACKGROUND: Recently, poly (lactic acid)/hydroxyapatite composite scaffolds have been widely used due to good biodegradation and biocompatibility. But poly (lactic acid)/hydroxyapatite composite material can not satisfy the requirements of ideal tissue-engineered scaffold materials owing to drawbacks in some aspects including enhancing material surface binding, adjusting material degradation velocity, and improving material intensity.
OBJECTIVE: To investigate the structural morphology and surface hydrophilicity of nanometer fiber membrane prepared by electrospinning.
METHODS: Poly(lactic acid), poly (3-hydroxybutyrate-co-4-hydroxybutyrate), and poly(propylene carbonate) nanometer fiber membranes were respectively prepared by electrospinning. The structural morphology of these three nanometer fiber membranes, as well as the surface hydrophilicity after soaking in phosphate buffered saline (37 ℃, pH 7.4) similar to human body environment for different time periods, was observed through the use of scanning electron microscope.
RESULTS AND CONCLUSION: Poly(lactic acid), poly(3-hydroxybutyrate-co-4-hydroxybutyrate), and poly(propylene carbonate) could be prepared into micro- and nano-sized fiber structure by electrospinning. Different fiber diameters of nanometer fiber membranes could be produced by controlling preparation parameters. With the prolonged soaking time in culture medium, the contact angle of three fiber members was reduced greatly and surface hydrophilicity was gradually enhanced.

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