中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (12): 2245-2248.doi: 10.3969/j.issn.1673-8225.2010.12.039

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

食管静脉曲张治疗硬化剂的选择及其性能评价

朱艳萍，赵  芮，蒋丹娜   

  1. 齐齐哈尔市第一医院消化内科，黑龙江省齐齐哈尔市   161005
  • 出版日期:2010-03-19 发布日期:2010-03-19
  • 作者简介:朱艳萍，女，1971年生，河北省故城县人，汉族，1995年佳木斯医学院毕业，副主任医师，主要从事消化系统疾病的研究。 zhuyanping1971@163.com

Selection and evaluation of hardeners in esophageal varices treatment

Thu Yan-ping, Zhao Rui, Jiang Dan-na   

  1. Department of Gastroenterology, Qiqihar First Hospital, Qiqihar  161005, Heilongjiang Province, China
  • Online:2010-03-19 Published:2010-03-19
  • About author:Zhu Yan-ping, Associate chief physician, Department of Gastroenterology, Qiqihar First Hospital, Qiqihar 161005, Heilongjiang Province, China zhuyanping1971@163.com

PDF

571

被引次数

14

摘要：

目的：评价内镜下食管静脉曲张治疗中硬化剂的性能，寻找适合的硬化剂。
方法：以“内镜，食管静脉曲张，硬化剂” 为中文关键词，“Endoscopy，Esophageal varix，Hardener” 为英文关键词，采用计算机检索1993-01/2009-10相关文章。纳入与有关内镜下食管静脉曲张治疗与硬化剂相关的文章；排除重复研究或Meta分析类文章。以20篇文献为主重点进行了讨论内镜下食管静脉曲张治疗中硬化剂及其性能。
结果：目前市场上有多种硬化剂可供选择，1%乙氧硬化醇效果好，副作用相对较小，但价格昂贵；无水乙醇虽然价格便宜，但其缺点是溃疡发生率高；5%的鱼肝油酸钠便宜，止血效果亦佳，不良反应的发生率亦不高。
结论：虽然硬化剂在治疗食管静脉曲张中止血效果明显，但是其并发症也有很多。如何注意处理并发症以及采用介入合并治疗提高止血效果成为进一步研究的重点。

关键词: 硬化剂, 内镜, 食管静脉曲张, 医用生物材料, 并发症

Abstract:

BACKGROUND: To select a suitable hardener via evaluating the hardener performance in endoscopic esophageal varices treatment. 
METHODS: Papers published from January 1993 to October 2009 were searched with key words of “endoscopy, esophageal varix and hardener” both in English and Chinese. Documents with regard to hardeners in esophageal varices treatment were included; repetition studies or Metal analysis were excluded. Totally 17 documents were selected to discuss the performance of hardener in esophageal varices treatment. 
RESULTS: Plenty of hardeners could be selected with each advantage. The 1% aethoxysklerol exhibited good therapeutic effect with little adverse reaction, but cost much; the drawback of high ulcer rate of dehydrated alcohol restricted its application despite low cost; 5% sodium morrhuate showed its superiority in cost, hemostasis, as well as low adverse reaction.
CONCLUSION: Hardeners have shown obvious hemostasis effect with complications in esophageal varices treatment. Thus, how to handle complications and enhancing hemostasis by combing hardeners with interventional therapy becomes a research focus.

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