中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (12): 2111-2113.doi: 10.3969/j.issn.1673-8225.2010.12.006

• 生物材料基础实验 basic experiments of biomaterials • 上一篇    下一篇

聚乙交酯编织型泌尿管支架的制备工艺

沈志静，陈南梁   

  1. 东华大学纺织学院，上海市 201620
  • 出版日期:2010-03-19 发布日期:2010-03-19
  • 作者简介:沈志静★，女，1984年生，上海市人，东华大学在读硕士，主要从事纺织工程生物医用研究。 jingjing.szj@gmail.com

Preparation technics of polyglycolic acid braiding urethral scaffold

Shen Zhi-jing, Chen Nan-liang   

  1. College of Textiles, Donghua University, Shanghai  201620, China
  • Online:2010-03-19 Published:2010-03-19
  • About author:Shen Zhi-jing★, Studying for master’s degree, College of Textiles, Donghua University, Shanghai 201620, China jingjing.szj@gmail.com

PDF

422

被引次数

11

摘要：

背景：尿道重建和修复除了需要合适的材料，更需要一种新的工艺和支架形式，其既可以仿生尿道的外观形态，又可以提供细胞生长的有利环境。
目的：探讨聚乙交酯材料制备编织型泌尿管支架的制备工艺。
方法：采用48tex 聚乙交酯长丝作为泌尿管支架的材料，由7股复丝组成，不加捻度，其中每根复丝中包含12根单纤。用二维三轴向的编织法构造，在95 ℃下，热定型5 min，热定型后，采用浸渍法涂层30 min，晾干后冷冻干燥4 h。
结果与结论：首次采用纺织的编织工艺方法，进行仿生模拟成型，所制得的聚乙交酯编织型泌尿管支架的孔隙率均在90%以上，满足泌尿管孔隙率的要求。

关键词: 尿道修复, 泌尿管支架, 编织, 孔隙率, 生物材料

Abstract:

BACKGROUND: The rebuilding and repair of the urethra need not only the appropriate material, but also a new craft and scaffold shape. The new configuration can simulate the shape of the urethra, and will provide a positive environment for cell growth.
OBJECTIVE: To explore the preparation of polyglycolic acid (PGA) as the braiding urethral scaffold material.
METHODS: The 48tex PGA filament was used as the urethral scaffold material, which was composed of 7 multifilaments, without twist. Each multifilament contained 12 single fibers. 2D-3 axis technics was utilized at 95 ℃, heat setting for 5 minutes. Following heat setting, impregnation method was used to coat for 30 minutes. Following drying in the open air, the sample was frozen and dried for 4 hours.
RESULTS AND CONCLUSION: The textile knitting technology was firstly used for bionic stimulation molding. Porosity of PGA braiding urethral scaffold is over 90%, which can meet the requirement of urethral porosity.

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