中国组织工程研究

中国组织工程研究

• 生物材料综述 biomaterial review • 上一篇    下一篇

天然组织工程材料诱导的血管生成：理论研究与应用进展

刘媛媛，吴海歌，姚子昂   

  1. 大连大学辽宁省生物有机化学重点实验室，辽宁省大连市 116622
  • 出版日期:2010-02-19 发布日期:2010-02-19
  • 通讯作者: 姚子昂，博士，副教授，大连大学辽宁省生物有机化学重点实验室，辽宁省大连市 116622 ziangyao@163.com
  • 作者简介:刘媛媛★，女，1984年生，山东省泰安市人，汉族，大连大学生物工程学院在读硕士，主要从事壳聚糖材料诱导血管生成的作用研究。 Liuyuanyuan.1019@yahoo.com.cn
  • 基金资助:

    国家自然科学基金项目(30600145)；辽宁省教育厅重点实验室项目资助(2009S007)。

Induced angiogenesis of natural tissue-engineering materials: Theoretical research and application progress

Liu Yuan-yuan, Wu Hai-ge, Yao Zi-ang   

  1. Liaoning Key Laboratory of Bioorganic Chemistry, Dalian University, Dalian 116622, Liaoning Province, China
  • Online:2010-02-19 Published:2010-02-19
  • Contact: Yao Zi-ang, Doctor, Associate professor, Liaoning Key Laboratory of Bioorganic Chemistry, Dalian University, Dalian 116622, Liaoning Province, China ziangyao@163.com
  • About author:Liu Yuan-yuan★, Studying for master’s degree, Liaoning Key Laboratory of Bioorganic Chemistry, Dalian University, Dalian 116622, Liaoning Province, China Liuyuanyuan.1019@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30600145*; Key Laboratory Project of Liaoning Provincial Education Department, No. 2009S007*

PDF

461

摘要：

背景：组织工程产品移植后的血管生成对其恢复缺损器官的功能具有重要的作用。天然组织工程材料具有良好的生物相容性和可降解性，在组织工程中应用较为广泛，其对血管生成的诱导作用可提高组织工程产品移植的成功率，因而近几年这方面的研究得到了学者们的关注。
目的：总结国内外天然组织工程材料诱导血管生成的实验研究，为今后天然组织工程材料应用临床提出理论基础。
方法：应用计算机检索PubMed、Springerlink数据库1995-01/2009-06的相关文献，检索词“tissue-engineering products,  natural materials”并限定文章语言种类为“English”。同时应用计算机检索中文期刊CNKI数据库1998-01/2009-06的相关文献。检索词为“组织工程材料、胶原蛋白、壳聚糖、纤维蛋白”等，限定文章语言种类为中文。对资料进行初审，纳入标准：天然组织工程材料如胶原蛋白、壳聚糖等诱导血管生成的体外体内实验研究。排除标准：重复性研究、较陈旧的文献。35篇可反映天然组织工程材料诱导血管生成的最新研究进展文献被纳入。
结果与结论：天然组织工程材料多由正常组织细胞外的高分子合成，本身包含许多生物信息，能够提供细胞所需的信号，对细胞的黏附及维持具有优势。文章探讨的胶原蛋白、壳聚糖、纤维蛋白3种天然组织工程材料在诱导血管生成方面具有优越性，但是天然材料在力学特性方面具有一定的局限性，因此构建以天然支架材料为主要材料且具有诱导血管生成作用的复合材料具有较强的应用前景。

关键词: 胶原蛋白, 壳聚糖, 纤维蛋白, 血管生成, 天然材料, 组织工程产品, 综述文献

Abstract:

BACKGROUND: After tissue-engineering products transplantation, angiogenesis played an important role in the function restoring of defective organs. The natural tissue-engineering materials had a wide application in tissue engineering due to its favorable biocompatibility and degradability, at the same time its pro-angiogenic function enhanced the achievement ratio of tissue-engineering products transplantation. Therefore, they attract much attention during recent years.
OBJECTIVE: To summarize the research status of incubating induced angiogenesis of tissue-engineered natural scaffold, so as to give some theoretical basis for further study on clinical application of natural tissue engineering materials.
METHODS: Relevant literatures in PubMed and Springerlink published between January1995 and June 2009 were searched by compute with the key words of “tissue-engineering products, natural materials” in English. While relevant Chinese articles in CKNI published between January1999 and June 2007 were also searched with the key words of “tissue-engineering natural materials, collagen, chitosan, fibrin” in Chinese. After primary selection, inclusive articles were those about study and experimental study of induced angiogenesis of tissue-engineered natural scaffold. Exclusive criteria: repetitive and obsolescent articles. A total 35 literatures were finally analyzed in accordance with the criteria.
RESULTS AND CONCLUSION: The natural tissue engineering materials were synthesized by macromolecules out of normal tissue, whose multiple bioinformation provided signal for cells and benefited for cellular adhesion and maintenance. Collagen protein, fiber gel protein, and chitosan summarized in this study were beneficial for inducing angiogenesis but limited to mechanical characteristics. Therefore, to construct natural materials inducing angiogenesisis is prospect.

中图分类号: