中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (2): 337-340.doi: 10.3969/j.issn.1673-8225.2010.02.035

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

组织工程皮肤的生物学特性及其临床应用评价

田宝祥，樊  华，刘凤彬，魏纯琳    

  1. 吉化集团公司总医院（北华大学医学院第二临床医院）烧伤整形科，吉林省吉林市 132022   
  • 出版日期:2010-01-08 发布日期:2010-01-08
  • 作者简介:田宝祥，男，1968年生，吉林省吉林市人，汉族，1992年北华大学毕业，副主任医师，主要从事烧伤整形方面的研究。 tianbaoxiang68@163.com

Biological property and clinical application of tissue engineered skin

Tian Bao-xiang, Fan Hua, Liu Feng-bin, Wei Chun-lin   

  1. Department of Burn and Plastics, General Hospital of Jilin Chemical Group (Second Clinical Hospital of Medical College Beihua University), Jilin   132022, Jilin Province, China
  • Online:2010-01-08 Published:2010-01-08
  • About author:Tian Bao-xiang, Associate chief physician, Department of Burn and Plastics, General Hospital of Jilin Chemical Group (Second Clinical Hospital of Medical College Beihua University), Jilin 132022, Jilin Province, China tianbaoxiang68@163.com

PDF

604

被引次数

7

摘要：

背景：尽管组织工程皮肤已应用于皮肤缺损的修复治疗，但远未达到完全代替永久性皮肤的程度。
目的：探讨不同类型组织工程皮肤的生物学特性及其临床应用评价。
方法：应用计算机检索Pubmed数据库(1990-01/2005-12)，检索词为“tissue-engineered skin”；应用计算机检索CNKI数据库(2002-01/2007-12)，检索词为“组织工程皮肤”。
结果与结论：计算机初检得到226篇文献，阅读标题和摘要进行初筛，排除因研究目的与此文无关或内容重复性的研究，共保留11篇文献进行分析。皮肤组织工程学目的是创建出组织学及功能特性上最接近人类皮肤组织的皮肤替代物，尽管目前已经有多种较为成熟的组织工程皮肤产品应用于临床，并且又研制了多种人工皮肤类型，但是它们大多数只是在结构上与人体皮肤类似，只具有皮肤的屏障功能，由于缺乏皮肤附件，所以它们并不具备完整的皮肤功能，并没有达到真正的皮肤重建。理想的皮肤替代物应具有表皮层和真皮层，真皮层可以快速的血管化和神经再分布，可促进快速的生理性的伤口修复；表皮层可以快速地获得充分的屏障和保护功能，与伤口创面充分一体化。一种良好的真皮载体除了应具备较好的组织相容性外，还必须具有一定的理化性能，如强度、柔软度、弹性、透气、透湿性能，才能保证真皮和创面贴附良好，为细胞生长提供理想的纤维支架，从而促进自体皮生长。组织工程皮肤应用前景良好，但目前在生物相容性、皮肤功能重建等方面仍存在各种问题需要解决。

Abstract:

BACKGROUND:Tissue engineered skin has been used to repair defect skin, but it is not as good as to completely replace permanent skin.
OBJECTIVE: To explore the biological characteristics and clinical application of various types of tissue engineered skin.
METHODS: Pubmed data (1990-01/2005-12) was retrieved by computer with the key words of “tissue-engineered skin”. CNKI database (2002-01/2007-12) was retrieved with the same key words.
RESULTS AND CONCLUSION: Totally 226 literatures were primarily selected. After reading titles and abstracts, studies addressing irrelative objective or repetitive content were excluded, and 11 literatures were included. The aim of skin tissue engineering is to create skin substitute that close to human skin in histology and functional characteristics. There were many mature tissue engineered skin in clinic, and various artificial skins were developed. Their structure was similar to human, but only had skin barrier function and lack of skin appendages, so they did not have complete skin function, and did not reach skin reestablishment. Ideal skin substitute should process cuticular layer and dermial layer. The dermial layer can reach rapid vascularization and nerve redistribution, can promote physiological wound repair. The cuticular layer can rapidly obtain full barrier and protection function, which can be fully integration with wound surface. A good dermial carrier has good histocompatibility, and a certain physical and chemical properties, such as strength, scratchability, elasticity, gas permeation, water vapor permeability. These can provide a good adherence between dermis and wound surface, offer an ideal fiber stent for cell growth, and finally promote autologous skin growth. Tissue engineered skin has good prospect, but there are many problems that should be solved in biocompatibility and skin function reestablishment.  

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