中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (31): 8293-8301.doi: 10.12307/2026.926

• 干细胞相关大数据分析 Stem cell-related big data analysis • 上一篇    下一篇

动物/人源外泌体骨组织修复：发展趋势的可视化分析

焦子怡，恩和吉日嘎拉，史国鹏，燕大洋，王  威，王  星，刘富灵，王海燕，李筱贺   

  1. 内蒙古医科大学基础医学院，内蒙古自治区呼和浩特市  010031
  • 收稿日期:2026-04-08 接受日期:2026-04-17 出版日期:2026-11-08 发布日期:2026-05-26
  • 通讯作者: 王海燕，硕士，教授，硕士生导师，内蒙古医科大学基础医学院，内蒙古自治区呼和浩特市 010031。 共同通讯作者：李筱贺，博士，教授，博士生导师，内蒙古医科大学基础医学院，内蒙古自治区呼和浩特市 010031
  • 作者简介:焦子怡，女，2000年生，汉族，辽宁省大连市人，内蒙古医科大学在读硕士，主要从事外泌体研究。 共同第一作者：恩和吉日嘎拉，女，1983年生，博士，副教授，硕士生导师，主要从事人体解剖与组织胚胎学工作，主要研究创面修复与组织再生。
  • 基金资助:
    内蒙古教育厅高等学校创新团队发展计划(NMGIRT2419)，项目负责人：王海燕；内蒙古自治区自然科学基金项目(2025LHMS08028)，项目负责人：王海燕；内蒙古自治区重点研发和成果转化计划(科技支撑黄河流域生态保护和高质量发展)(2025YFHH0237)，项目负责人：李筱贺；内蒙古教育厅高等学校创新团队发展计划(NMGIRT2227)，项目负责人：李筱贺；中央引导地方科技资金支持项目(2024ZY0127)，项目负责人：恩和吉日嘎拉；内蒙古自治区高等学校“青年科技英才支持计划”项目(NJYT24031)，项目负责人：恩和吉日嘎拉；大学生科技创新“英才培育”项目(YCPY2025023)，项目负责人：刘富灵

Bone tissue repair with animal/human-derived exosomes: visualization analysis of development trends

Jiao Ziyi, Enhejirigala, Shi Guopeng, Yan Dayang, Wang Wei, Wang Xing, Liu Fuling, Wang Haiyan, Li Xiaohe   

  1. School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010031, Inner Mongolia Autonomous Region, China
  • Received:2026-04-08 Accepted:2026-04-17 Online:2026-11-08 Published:2026-05-26
  • Contact: Wang Haiyan, MS, Professor, Master’s supervisor, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010031, Inner Mongolia Autonomous Region, China. Co-corresponding author: Li Xiaohe, PhD, Professor, Doctoral supervisor, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010031, Inner Mongolia Autonomous Region, China
  • About author:Jiao Ziyi, MS candidate, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010031, Inner Mongolia Autonomous Region, China. Enhejirigala, PhD, Associate professor, Master’s supervisor, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010031, Inner Mongolia Autonomous Region, China. Jiao Ziyi and Enhejirigala contributed equally to this work.
  • Supported by:
    Innovative Research Team in Universities of Inner Mongolia Autonomous Region, No. NMGIRT2419 (to WHY); Natural Science Foundation of Inner Mongolia Autonomous Region, No. 2025LHMS08028 (to WHY); Key Research and Development and Achievement Transformation Program of Inner Mongolia Autonomous Region (Science and Technology Support for Ecological Protection and High-Quality Development of the Yellow River Basin), No. 2025YFHH0237 (to LXH); Program for Innovative Research Team in Universities of Inner Mongolia Department of Education, No. NMGIRT2227 (to LXH); Project Supported by the Central Government Guidance Fund for Local Science and Technology, No. 2024ZY0127 (to Enhejirigala); Project of the “Young Scientific and Technological Talents Support Program” for Colleges and Universities in Inner Mongolia Autonomous Region, No. NJYT24031 (to Enhejirigala); “Talent Cultivation” Program for Scientific and Technological Innovation of College Students, No. YCPY2025023 (to LFL)

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摘要：

文题释义：

动物/人源外泌体：源自物种细胞或体液分泌的纳米级双层膜囊泡，作为无细胞治疗载体调控细胞通讯。
骨修复：针对因创伤、病理或先天因素导致的骨缺损，利用生物活性材料或因子(如外泌体)诱导机体自我再生能力，通过协同促进成骨分化、血管生成及调节免疫微环境，实现骨组织的结构重塑与功能恢复。
可视化分析：基于文献计量学原理，利用计算机算法(如CiteSpace、VOSviewer等软件)对海量文献数据进行挖掘与处理，构建知识图谱。通过直观的图形化方式展示特定学科领域的科学合作网络、研究热点演变及前沿趋势，揭示知识结构内部的动态关联与发展规律。

摘要
背景：动物/人源外泌体作为新型无细胞纳米载体，凭借低免疫原性及促血管化、促成骨的双重调控优势，成为再生医学的研究热点。然而，目前尚缺乏通过文献计量学对该领域研究现状及演化趋势的系统性分析。
目的：对动物/人源外泌体在骨组织修复中应用的相关文献进行可视化分析，探究该领域的研究热点及研究现状，为后续研究提供参考。
方法：从Web of Science核心合集和中国知网数据库中检索动物/人源外泌体在骨组织修复领域的相关文献，检索时限为2015-01-01/2025-11-27，使用Microsoft Office Excel2019、CiteSpace 6.4.R1、VOSviewer 1.6.20和R语言Bibliometrix进行统计分析和文献可视化分析。
结果与结论：①共纳入Web of Science核心合集英文文献403篇、中国知网中文文献152篇，发文量整体呈上升趋势且英文文献增速更快；②在Web of Science核心合集数据库中，中国发文量(303篇)居首，美国跨国合作能力最强，中介中心性为0.71；最多产机构与期刊分别为上海交通大学和《Journal of Nanobiotechnology》；③在分析的文献中，Furuta(2016)的被引次数最高，达360次，而在这些文献所引用的参考文献中，Kalluri(2020)的被引次数最多，为70次；④关键词共现及演化分析显示，核心热点为“外泌体”“骨再生”等；研究主题由早期的“炎症”“骨折愈合”等基础机制，逐步向“免疫调节”“血管生成”等应用层面演变，“水凝胶”正成为连接微观机制与宏观治疗的关键载体；⑤未来该领域将从单一机制验证向工程化产品转化，重点聚焦于免疫微环境调控及血管-骨再生偶联机制；此外，乳源外泌体因具备产量大、成本低及给药便捷等优势，有望成为实现低成本临床转化的重要新方向。

关键词: 动物来源外泌体, 人源外泌体, 骨组织修复, 文献计量学, 可视化分析, 间充质干细胞

Abstract: BACKGROUND: As novel cell-free nanocarriers, animal- and human-derived exosomes have become research hotspots in regenerative medicine, thanks to their low immunogenicity and dual regulatory advantages in promoting vascularization and osteogenesis. However, there is currently a lack of systematic bibliometric analysis regarding the research status and evolutionary trends in this field.
OBJECTIVE: To perform a visualization analysis of relevant literature concerning the application of animal/human-derived exosomes in bone tissue repair, exploring research hotspots and current status to provide a reference for future studies.
METHODS: Literature related to animal/human-derived exosomes in the field of bone tissue repair published between January 1, 2015, and November 27, 2025, was retrieved from the Web of Science Core Collection and the China National Knowledge Infrastructure. Statistical and visualization analyses were conducted using Microsoft Office Excel 2019, CiteSpace 6.4.R1, VOSviewer 1.6.20, and the R-Bibliometrix package.
RESULTS AND CONCLUSION: (1) A total of 403 English publications from Web of Science Core Collection and 152 Chinese publications from China National Knowledge Infrastructure were included. The overall volume of publications shows an upward trend, with English literature growing at a faster rate. (2) In the Web of Science Core Collection database, China ranks first in the number of publications (303 articles), while the United States exhibits the strongest international collaboration capacity, with a betweenness centrality of 0.71. The most prolific institution and journal are Shanghai Jiao Tong University and the Journal of Nanobiotechnology, respectively. (3) Among the analyzed literature, Furuta (2016) has the highest citation count (360). Within the references cited by these documents, Kalluri (2020) is the most frequently cited (70 times). (4) Keyword co-occurrence and evolution analysis show that “exosomes” and “bone regeneration” are core hotspots. Research themes have evolved from early basic mechanisms such as “inflammation” and “fracture healing” toward application levels like “immunomodulation” and “angiogenesis.” “Hydrogels” are emerging as a key carrier linking microscopic mechanisms to macroscopic therapy. (5) Future research will shift from single-mechanism validation to engineered product transformation, focusing on the regulation of the immune microenvironment and the coupling mechanism of vascular-bone regeneration. Additionally, milk-derived exosomes are expected to become a significant new direction for low-cost clinical translation due to their high yield, low cost, and ease of administration.

Key words: animal-derived exosomes, human-derived exosomes, bone tissue repair, bibliometrics, visualization analysis, mesenchymal stem cells

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